Morphometric analysis of the left ventricle myocardial layers under heart hypertrophy was carried out. Values of tissue parameters on the 3rd, 10th and 24th days after 50% coarctation of the abdominal aorta were received. Is shown the heart functioning under conditions of myocardial compensatory hypertrophy development is characterized by expressed zones and different directions of changes of quantitative parameters of tissue components. The single injection of HMP (Hydra morphogen peptide) made the development of myocardial hypertrophy easy at early stages, decreasing depth of manifestations morphologic changes and perhaps affected the time of their development.
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Naunyn Schmiedebergs Arch Pharmacol
January 2025
Department of Pharmaceutics, School of Pharmaceutical Sciences, Delhi Pharmaceutical Sciences and Research University, Pushp Vihar, New Delhi, 110017, India.
Chronic wounds significantly contribute to disability and affect the mortality rate in diabetic patients. In addition, pressure ulcers, diabetic foot ulcers, arterial ulcers, and venous ulcers pose a significant health burden due to their associated morbidity and death. The complex healing process, environmental factors, and genetic factors have been identified as the rate-limiting stages of chronic wound healing.
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January 2025
Jiangxi University of Chinese Medicine, Research Center for Differentiation and Development of CM Basic Theory of Jiangxi University of Chinese Medicine, Jiangxi Province Key Laboratory of CM Etiopathogenesis, Nanchang, Jiangxi, China, 330004, 330004, nan chang, CHINA.
Qingzao Jiufei Decoction (QD) is a renowned prescription for nourishing lung Yin to treat lung related diseases in ancient and modern times. It has been reported that QD can effectively inhibit the growth of lung cancer, but the material basis and mechanism of its treatment of LC remain to be further studied. In this experiment, we combined serum pharmacochemistry and proteomics to study the pharmacodynamic material basis and mechanism of QD against lung cancer.
View Article and Find Full Text PDFAdv Sci (Weinh)
January 2025
Department of Stomatology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Oral diseases rank among the most prevalent clinical conditions globally, typically involving detrimental factors such as infection, inflammation, and injury in their occurrence, development, and outcomes. The concentration of reactive oxygen species (ROS) within cells has been demonstrated as a pivotal player in modulating these intricate pathological processes, exerting significant roles in restoring oral functionality and maintaining tissue structural integrity. Due to their enzyme-like catalytic properties, unique composition, and intelligent design, ROS-based nanomaterials have garnered considerable attention in oral nanomedicine.
View Article and Find Full Text PDFEnviron Toxicol Chem
January 2025
NCASI, Anacortes, United States.
Numeric water quality criteria development approaches for the protection of aquatic life and human health incorporate bioaccumulation factors (BAFs) as key exposure pathways. These are typically derived from field-collected tissue and ambient water concentration data, and are often highly variable within and across species. Existing guidance for conducting BAF field studies is necessarily general to accommodate research objectives, ecosystem characteristics, and the chemicals and species of interest.
View Article and Find Full Text PDFEnviron Toxicol Chem
January 2025
School of Science, Royal Melbourne Institute of Technology, Melbourne, Victoria, Australia.
Heavy metals are cumulative toxicants that frequently create negative health effects for waterbirds inhibiting contaminated freshwater systems. Although levels of exposure to heavy metals have been well documented for many waterbird species, the adverse effects of exposure remain relatively poorly understood. One emerging field that allows the exploration of such effects is metabolomics.
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