Findings are described of small (8-10 microns) coccidian oocysts in the stools of 9 patients presenting with diarrhoea, all of whom with a history of travelling in South Asia and/or South America in the years 1986 and 1987. There was no indication of immunodeficiency. These oocysts, which were immature in freshly excreted stools, could be induced to sporulate into a two-sporocysts stage and are now recognized as Cyclospora spec.
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JAMA Netw Open
January 2025
Johns Hopkins Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Importance: Obesity, a chronic disease with escalating global prevalence, poses considerable health risks. Glucagon-like peptide 1 receptor agonists (GLP-1RAs), including liraglutide, semaglutide, and tirzepatide, have demonstrated efficacy for weight loss in clinical trials. The paradigm shift in the approach to obesity management drugs (OMDs) may offer an opportunity to examine online search activity and prescription trends.
View Article and Find Full Text PDFPhysiol Rep
February 2025
Motion and Exercise Science, University of Stuttgart, Stuttgart, Germany.
The maintenance of an appropriate ratio of body fat to muscle mass is essential for the preservation of health and performance, as excessive body fat is associated with an increased risk of various diseases. Accurate body composition assessment requires precise segmentation of structures. In this study we developed a novel automatic machine learning approach for volumetric segmentation and quantitative assessment of MRI volumes and investigated the efficacy of using a machine learning algorithm to assess muscle, subcutaneous adipose tissue (SAT), and bone volume of the thigh before and after a strength training.
View Article and Find Full Text PDFJ Child Sex Abus
January 2025
Georgia State University, Atlanta, GA, USA.
Characteristics associated with individuals who frequent the emergency department at higher rates have been well established; however, factors associated with greater emergency department visits following a recent sexual assault are largely unknown. The current study evaluated the associations between pre-assault factors such as substance use and physical injuries, assault characteristics such as genital injury, non-genital injury, alcohol or drug use involvement, intimate partner involvement, and emergency department visits one-year after a sexual assault medical forensic exam (SAMFE). The current study included a medical record review of 123 individuals who received a SAMFE at a hospital in the United States.
View Article and Find Full Text PDFBiochem Cell Biol
January 2025
Department of Histology and Embryology, School of Medicine, Shenzhen Campus of Sun Yat-Sen University, Sun Yat-Sen University, Shenzhen, China.
Idiopathic pulmonary fibrosis (IPF) is a progressive and irreversible lung disease with high mortality and limited treatment options. While single-dose bleomycin-induced models are commonly used to investigate the pathogenesis of IPF, they fail to adequately replicate the complex pathological features in human patients, thereby hindering comprehensive investigations. Previous studies utilizing repetitive bleomycin injections have demonstrated a closer resemblance to human IPF pathology; however, the time- and resource-intensive nature of this approach presents significant drawbacks.
View Article and Find Full Text PDFPrev Med Rep
February 2025
Departments of Medicine, Health, and Society & Sociology, Vanderbilt University, 2201 West End Ave, Nashville, TN 37235, USA.
Introduction: Cigarette smoking is among the largest risk factors for cognitive decline in later life. This study examines the associations between hospitality smoke-free coverage in the US and the prevalence of self-rated cognitive function decline and disparities therein.
Methods: I use the repeated cross-sectional Behavioral Risk Factor Surveillance data collected between 2017 and 2022 from a sample of Americans 45 years and older and estimate logistic regression models predicting self-rated cognitive function decline by calculated smoke-free hospitality coverage in restaurants and bars.
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