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Lack of TLR9 exacerbates ocular impairment and visual loss during systemic Cryptococcus gattii infection.
J Infect Dis
January 2025
Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 21941-902, Brazil.
Cryptococcus gattii is a saprophytic basidiomycete that grows in the environment and can cause systemic cryptococcosis. Ocular cryptococcosis causes blindness and is commonly associated with central nervous system (CNS) infection. Toll-like receptor 9 (TLR9) can control cryptococcosis and another mycosis.
View Article and Find Full Text PDFOcular and Plasma Pharmacokinetics of Sitagliptin Eye Drops: Preclinical Data.
Pharmaceuticals (Basel)
November 2024
Diabetes and Metabolism Research Unit, Vall d'Hebron Research Institute, 08035 Barcelona, Spain.
Early stages of diabetic retinopathy are currently considered an unmet medical need due to the lack of effective treatments beyond proper monitoring and control of glycemia and blood pressure. Sitagliptin eye drops have emerged as a new therapeutic approach against early stages of the disease, as they can prevent its main hallmarks, including both neurodegeneration and microvascular impairment. Interestingly, all of these effects occur without any glycemic systemic improvement.
View Article and Find Full Text PDFRole of Emotional Support and Socio-Cultural Atmosphere on the Experience Caesaran Patients: A Systematic Review.
Iran J Public Health
December 2024
Department of Health Promotion and Behavioral Sciences, Faculty of Public Health, Universitas Hasanuddin, Indonesia.
Background: The global maternal mortality rate has increased annually. This study aimed to examine the role of emotional support and the social support theraphy on the experience of emergency caesarean deliveries.
Methods: The narrative study was conducted using scientific journal database sources from PubMed, Proquest, Ebsco, Science Direct, and Google Scholar from 2016 to 2023.
Two cases of fatal insulin homicide resolved using combined immunohistochemistry and immunofluorescence techniques.
Forensic Sci Med Pathol
December 2024
Department of Forensic Medicine, Tongji Medical College, Huazhong University of Science and Technology, No. 13 Hangkong Road, Wuhan, 430030, People's Republic of China.
Diabetes is a prevalent disease in modern society. Since the development and widespread use of synthetic insulin, its therapeutic application has become globally recognized for managing diabetes. However, excessive administration of insulin may lead to fatal outcomes.
View Article and Find Full Text PDFCase report: Unveiling the silent threat in the ICU - a case of disseminated invasive aspergillosis in a patient with fulminant myocarditis.
Front Immunol
December 2024
Fourth Department of Critical Care Medicine, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou, Fujian, China.
Invasive aspergillosis (IA) significantly increases mortality in critically ill patients in the ICU and its occurrence is closely related to immunocompromise. Dissemination of IA is easily misdiagnosed and mistreated due to its ability to invade multiple systems throughout the body and lack of typical clinical manifestations. In this case, a 25-year-old previously healthy woman was hospitalized with fulminant myocarditis and treated with veno-arterial extracorporeal membrane pulmonary oxygenation (VA-ECMO) support and intravenous acyclovir, high-dose methylprednisolone, and immunoglobulin.
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