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Viruses and psychiatric disorders: We have not crossed the borderline from hypothesis to proof yet (Review).
Mol Med Rep
March 2025
2nd Department of Psychiatry, National and Kapodistrian University of Athens, Attikon University Hospital, 12462 Athens, Greece.
Most psychiatric disorders are heterogeneous and are attributed to the synergistic action of a multitude of factors. It is generally accepted that psychiatric disorders are the outcome of interactions between genetic predisposition and environmental perturbations, which involve psychosocial stress, or alterations in the physiological state of the organism. A number of hypotheses have been presented on such environmental influences that may include direct insults such as injury, malnutrition and hostile living conditions, or indirect sequelae following infection from viruses such as influenza, arboviruses, enteroviruses and several herpesviruses, or the differential expression of human endogenous retroviruses.
View Article and Find Full Text PDFSentence Comprehension in Spanish-Speaking Children With Hearing Loss: On the Integration of Morphosyntactic and Lexico-Semantic Cues.
J Speech Lang Hear Res
December 2024
Escuela de Gobierno, Universidad Torcuato Di Tella, Buenos Aires, Argentina.
Purpose: Children with hearing loss (CHL) who use hearing devices (cochlear implants or hearing aids) and communicate orally have trouble comprehending sentences with noncanonical order. This study explores sentence comprehension strategies in Spanish-speaking CHL, focusing on their ability to integrate morphosyntactic cues (word order, morphological case marking) with verbs differing in their syntax-to-semantics configuration.
Method: Fifty-eight Spanish-speaking CHL and 58 children with typical hearing (CTH) with a hearing age of 3;5-7;8 (years;months; i.
A New Tool for Extracting Static and Dynamic Parameters from [F]F-DOPA PET/CT in Pediatric Gliomas.
J Clin Med
October 2024
Department of Informatics, Bioengineering, Robotics and System Engineering (DIBRIS), University of Genoa, 16145 Genoa, Italy.
Article Synopsis
- PET imaging with [F]F-DOPA shows promise for assessing pediatric brain gliomas, but manual extraction of data is slow and inconsistent.
- A new semi-automated Python framework was developed to streamline the processing of PET images and improve efficiency and accuracy in calculating clinical scores.
- The study found that this new method significantly improved reproducibility in extracting important tumor metrics and reduced the variability associated with human input.
Autodelineation methods in a simulated fully automated proton therapy workflow for esophageal cancer.
Phys Imaging Radiat Oncol
October 2024
KU Leuven, Department of Oncology, Laboratory of Experimental Radiotherapy, Leuven, Belgium.
Article Synopsis
- ProtOnART is a technique that improves proton therapy for esophageal cancer by adapting to changes in patient anatomy during treatment, focusing on effective autodelineation methods for target and risk areas.
- A study of 15 patients compared various autodelineation methods and their effectiveness in creating adaptive treatment plans, finding that deformation techniques yielded better results for organs at risk and clinical target volumes.
- The results showed that while most adaptive treatment plans met initial evaluation goals, significant challenges remained in ensuring adequate coverage of clinical targets, necessitating manual intervention for clinical acceptance.
HIV status disclosure in the era of treat-all: the complexities of societal expectations and disclosure in marital relationships in Shinyanga, Tanzania.
AIDS Care
December 2024
Amsterdam Institute for Global Health and Development, Amsterdam, the Netherlands.
Robust advancements in clinical treatment of people living with HIV (PLHIV) have resulted in the current "treatment as prevention" strategy: the inability to transmit the virus when it is undetectable. Nevertheless, disclosure within marital relationships remains important to adhere optimally to treatment and further limit transmission in the era of treat-all. Disclosure, however, can have serious social repercussions, particularly for women.
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