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The Vulvodynia Primary Care Toolkit: results of a mixed-method evaluation with community-based family physicians in British Columbia.
Fam Pract
January 2025
Department of Obstetrics and Gynaecology, 2775 Laurel Street, University of British Columbia, Vancouver, British Columbia, V5Z 1M9, Canada.
Background: Healthcare providers often lack awareness, knowledge, and confidence in managing vulvodynia, which can lead to difficulties with diagnosis and treatment for individuals with the condition.
Objective: To develop and test an educational online toolkit tailored to supporting community-based primary care providers with diagnosis, treatment, and patient support for vulvodynia.
Methods: A sample of 19 community-based family physicians completed online surveys before and after testing the Vulvodynia Primary Care Toolkit (the toolkit hereafter) in their practice for 6 months.
The role of interoceptive sensibility on central sensitization to pain in vulvodynia.
J Sex Med
January 2025
Italian Association for Applied Sexology and Psychology, 20124 Milan, Italy.
Background: Interoception may be linked to central sensitization in chronic pain.
Aim: We aimed to provide evidence about the role of interoceptive sensibility on central sensitization in vulvodynia.
Methods: In this cross-sectional study, a sample of females who received a diagnosis of vulvodynia filled out validated questionnaires relative to the individual level of interoceptive sensibility and the symptoms of central sensitization.
Obstetric outcomes in women with vulvodynia and vaginismus: a systematic review.
Arch Gynecol Obstet
January 2025
Centre for Clinical Epidemiology and Community Studies, Jewish General Hospital, Pav H, Room 412, 3755 Côte Ste-Catherine, Montreal, QC, H3T 1E2, Canada.
Purpose: Vulvodynia and vaginismus are pain disorders associated with adverse pregnancy outcomes. The few published studies addressing this topic were limited in terms of the different outcomes studied; hence, the purpose of our study was to perform the first systematic review examining maternal, neonatal and obstetric outcomes in patients with vulvodynia and/or vaginismus (VV).
Methods: We conducted a systematic review searching PubMed, EMBASE, Cochrane Library and SCOPUS until November 2023 for observational studies reporting maternal and/or neonatal outcomes of VV in pregnancy.
Pelvic floor muscle activation amplitude at rest, during voluntary contraction, and during Valsalva maneuver-a comparison between those with and without provoked vestibulodynia.
J Sex Med
December 2024
School of Psychology, Faculty of Arts and Sciences, Queen's University, Kingston, Ontario, K7L 3N6, Canada.
Background: The neuromuscular contribution to increased tone of the pelvic floor muscles (PFMs) observed among those with provoked vestibulodynia (PVD) is unclear.
Aim: To determine if PFM activity differs between those with provoked PVD and pain free controls, and if the extent of PFM activation at rest or during activities is associated with pain sensitivity at the vulvar vestibule, psychological, and/or psychosexual outcomes.
Methods: This observational case-control study included forty-two volunteers with PVD and 43 controls with no history of vulvar pain.
Schwann cell C5aR1 co-opts inflammasome NLRP1 to sustain pain in a mouse model of endometriosis.
Nat Commun
November 2024
Department of Health Science, Clinical Pharmacology and Oncology Section, University of Florence, Florence, Italy.
Over 60% of women with endometriosis experience abdominopelvic pain and broader pain manifestations, including chronic back pain, fibromyalgia, chronic fatigue, vulvodynia, and migraine. Although the imbalance of proinflammatory mediators, including the complement component C5a, is associated with endometriosis-related pain, the mechanisms causing widespread pain and the C5a role remain unclear. Female mice and women with endometriosis exhibit increased plasma C5a levels and pain.
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