Partial thyroxine-binding globulin (TBG) deficiency, with a median TBG of 2.3 mg/l, was found in 25 mature babies with hypothyroxinaemia (3 girls and 22 boys) from our screening programme for congenital hypothyroidism during 1988-1990. Analysis of the HLA system revealed the possibility that antigen DR6 may be considered as a risk factor for TBG deficiency (44.0 vs. 19.2%) and DR2 as a protective factor (16.0 vs. 37.5%). Similar laboratory findings were also present in 16 mothers and 1 father.
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- Interference with these carrier proteins could disrupt the thyroid system, prompting the need for more data on chemicals that impact them.
- A fluorescence-based screening assay tested over 1,400 chemicals, identifying 714 that significantly affected binding and narrowing down to 141 that showed potential for disrupting thyroid hormone balance, aiding future testing and data prediction efforts.
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