In a systematic study of the relationship between the chemical structure and beta-adrenolytic activity, eleven derivatives of the 4-alkoxysubstituted phenylcarbamic acids were prepared. The beta-adrenolytic efficiency of the compounds was studied in the isolated spontaneously beating guinea-pig atria and expressed as pA2 values against isoprenaline tachycardia. Negative chronotropic and antidysrhythmic activity were also evaluated. All of the compounds studied were local anesthetically active and their indexes of efficiency were 3-50 fold higher in comparison with standards cocaine and procaine. The acute toxicity of the compounds was within the acceptable limits.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Structural studies of hydrated rare earth nitrates within the stereoatomic model of crystal structures.
Acta Crystallogr B Struct Sci Cryst Eng Mater
February 2025
MIREA - Russian Technological University, 78 Vernadsky Avenue, Moscow, 119454, Russian Federation.
All crystal structures containing nitrate ions, water molecules and one of the rare earth (RE) metal atoms (La-Lu, Y, Sc) were extracted from the Inorganic Crystal Structure Database. The composition of the identified compounds is analyzed in terms of the number of coordinated and uncoordinated water molecules and nitrate ions. Among the resulting compounds, several isotypic and morphotropic series are observed.
View Article and Find Full Text PDFCarbene-Functionalized Bulky-Cyclopentadiene Rings.
Chemistry
January 2025
Indian Institute of Technology Madras, Department of Chemistry, Chennai, Chennai, INDIA.
A series of significantly bulky mono- and di-substituted cyclic alkyl-amino carbene (cAAC)- functionalized cyclopentadiene ring (Cp) compounds were synthesized. The functionalization of the Cp ring with cAAC ligands makes them significantly bulkier, while retaining their ligation properties. These compounds display interesting fluorescence properties.
View Article and Find Full Text PDFAnti-HIV-1 Effect of the Fluoroquinolone Enoxacin and Modulation of Pro-Viral hsa-miR-132 Processing in CEM-SS Cells.
Noncoding RNA
January 2025
Institute of Pharmaceutical Sciences, ETH Zurich, 8093 Zurich, Switzerland.
Background: Despite tremendous advances in antiretroviral therapy (ART) against HIV-1 infections, no cure or vaccination is available. Therefore, discovering novel therapeutic strategies remains an urgent need. In that sense, miRNAs and miRNA therapeutics have moved intensively into the focus of recent HIV-1-related investigations.
View Article and Find Full Text PDFCurrent Approaches for Genetic Manipulation of spp.-Key Bacteria for Biotechnology and Environment.
BioTech (Basel)
January 2025
Valent BioSciences, Biorational Research Center, 1910 Innovation Way, Suite 100, Libertyville, IL 60048, USA.
Organisms from the genus feature actinobacteria with complex developmental cycles and a great ability to produce a variety of natural products. These soil bacteria produce more than 2/3 of antibiotics used in medicine, and a large variety of bioactive compounds for industrial, medical and agricultural use. Although spp.
View Article and Find Full Text PDFRapid Separation of Representative Monomer Compound Rutin From Natural Product by Molecularly Imprinted Macroporous Adsorption Resin.
J Sep Sci
January 2025
School of Chemistry and Environment, Southwest Minzu University, Chengdu, China.
Monomer compounds from natural products are the major source of active pharmaceutical molecules, which provide great opportunities for discovering of new drugs. However, natural products contain a large number of rather complex compounds. It is difficult to obtain high-purity monomer compounds from complex natural products.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!