Background And Objective: Although continuous spinal anesthesia with microcatheters has a number of advantages, there are also some drawbacks: technical problems in advancing the catheter, the possibility of traumatizing neural structures, the development of cauda equina syndrome, and maldistribution of the local anesthetic.
Methods: Spinaloscopy was performed with a 2-mm-diameter endoscope in fresh cadavers to visualize the fate of the catheters, as well as the distribution of the local anesthetic administered through these fine-bore catheters. Midline and paramedian approach achieved an easy insertion of the 28-gauge catheter as long as the 22-gauge needle was not advanced too far into the subarachnoid space, thereby making it impossible for the catheter to bend at the anterior wall of the dura mater.
Results: Injection of methylene blue-colored hyperbaric local anesthetic through the catheter revealed an inhomogenous distribution with pooling in the caudal segments. After the catheter tip leaves the needle, the catheter should be advanced only 2-3 cm to avoid coiling, possible damage of the nerve roots, or malpositioning in preformed pouches.
Conclusion: To take advantage of continuous spinal anesthesia, a meticulous technique is required.
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Background: Alzheimer's Disease (AD) is a major neurodegenerative disorder characterized by amyloid deposits in brain tissues and representing a continuously increasing global burden in need of disease-modifying therapeutic options. Amyloid beta 1-42 and 1-40 peptides and the amyloid beta 1-42/1-40 ratio are hallmarks of AD and are commonly monitored in Cerebro-Spinal Fluid (CSF) along other AD biomarkers, to support diagnosis and management of AD patients. Over the past few years, blood-based AD biomarkers have emerged as highly relevant and more practical alternatives to CSF biomarkers, and further technical performance characterization of the associated assays would be beneficial to the AD research and medical community.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
National Institute of Neurological Disorders and Stroke, Rockville, MD, USA.
Background: Access to biospecimens is an oft cited challenge to the progress in research on neurological disorders. Access to clinical biospecimens for development of validated biomarkers and improved cellular models of Alzheimer's Disease and Alzheimer's Disease Related Dementias (AD/ADRD) are cited as priorities across several NIH AD/ADRD Research Implementation Milestones (https://www.nia.
View Article and Find Full Text PDFActa Chir Orthop Traumatol Cech
January 2025
Neurochirurgická klinika Fakultní nemocnice Olomouc.
Purpose Of The Study: The annual number of spinal fusion procedures has been increasing and is well documented worldwide. The O-arm is slowly becoming the standard for transpedicular screw insertion. The accuracy and safety of this method have been confirmed by many studies.
View Article and Find Full Text PDFArthrosc Tech
December 2024
Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Tearing of the subscapularis tendon is a common shoulder injury that typically requires arthroscopic repair. The suture-passing device is a standard tool for repairing the subscapularis tendon. However, it poses the risk of device breakage and may cause additional damage to the tendon.
View Article and Find Full Text PDFAm J Obstet Gynecol MFM
January 2025
Department of Anaesthesiology and Critical Care, Jawaharlal Institute of Post Graduate Medical Education and Research, Puducherry, India. Electronic address:
Background: Preclinical studies have documented the role of alpha-adrenergic agonists in myometrial contraction. Phenylephrine is frequently used to prevent and treat post-spinal hypotension during cesarean delivery. We hypothesized phenylephrine would reduce postpartum blood loss due to alpha-1 receptor-mediated uterine and vascular smooth muscle contraction.
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