The biology, physiology, husbandry, and handling of the hedgehog are described. Diseases and conditions of practical significance are reviewed.
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http://dx.doi.org/10.1016/s0195-5616(94)50006-8 | DOI Listing |
J Mol Neurosci
January 2025
Gilgamesh Ahliya University, Baghdad, Iraq.
Glioma is a highly aggressive and invasive brain tumor with limited treatment options, highlighting the need for novel therapeutic approaches. Kinesin superfamily proteins (KIFs) are a diverse group of motor proteins that play essential roles in cellular processes such as mitosis, intracellular transport, and signal transduction, all of which are crucial for tumorigenesis. This review focuses on the multifaceted role of KIFs in glioma, examining their clinical relevance, contribution to tumor progression, and potential as therapeutic targets.
View Article and Find Full Text PDFSci Rep
January 2025
Physical Plasma Medicine Laboratories, Department of Gynecology and Gynecological Oncology, University Hospital Bonn, Bonn, Germany.
Non-invasive physical plasma (NIPP) has been used effectively for wound healing in human medicine for over two decades. The advantages are that NIPP has few side effects, is painless and gentle on the tissue. The therapeutic effect is mediated by reactive oxygen species (ROS).
View Article and Find Full Text PDFElife
January 2025
Department of Neurology, Weill Institute for Neuroscience, University of California San Francisco, San Francisco, United States.
Mutations in Sonic Hedgehog (SHH) signaling pathway genes, for example, (SUFU), drive granule neuron precursors (GNP) to form medulloblastomas (MB). However, how different molecular lesions in the Shh pathway drive transformation is frequently unclear, and mutations in the cerebellum seem distinct. In this study, we show that fibroblast growth factor 5 (FGF5) signaling is integral for many infantile MB cases and that expression is uniquely upregulated in infantile MB tumors.
View Article and Find Full Text PDFbioRxiv
January 2025
Department of Molecular and Cell Biology, School of Natural Sciences, University of California Merced, Merced, California, USA.
The GPCR-like protein Smoothened (Smo) plays a pivotal role in the Hedgehog (Hh) pathway. To initiate Hh signaling, active Smo binds to and inhibits the catalytic subunit of PKA in the primary cilium, a process facilitated by G protein-coupled receptor kinase 2 (Grk2). However, the precise regulatory mechanisms underlying this process, as well as the events preceding and following Smo activation, remain poorly understood.
View Article and Find Full Text PDFVet World
November 2024
Department of Public Health, College of Veterinary Medicine, University of Basrah, Basra, Iraq.
Background And Aim: is a highly contagious zoonotic bacterial micro-organism. This study aimed to estimate the prevalence of in dogs using serological and molecular methods. Furthermore, a sequencing analysis of dog isolates was conducted.
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