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Background: Varicella-zoster virus (VZV) central nervous system infection is typically observed in immunocompromised patients, and there is a lack of studies involving large samples of non-immunocompromised individuals. In this study, we retrospectively analyzed 108 non-immunocompromised patients diagnosed with VZV central nervous system infection.

Methods: This retrospective study was conducted in the Department of Neurology, Affiliated Nanjing Brain Hospital, Nanjing Medical University, China.

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Background: Progressive familial intrahepatic cholestasis type 1 (PFIC-1) is a genetic cholestatic disease causing end-stage liver disease, which needs liver transplantation (LT). Simultaneous biliary diversion (BD) was recommended to prevent allograft steatosis after transplantation, while increasing the risk of infection. Here, an attempt was made to perform BD using appendix to prevent bacterial translocation after LT.

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Unlabelled: Sparsentan, a dual endothelin receptor A inhibitor and angiotensin blocker, reduced proteinuria in patients with focal segmental glomerulosclerosis (FSGS) in Phase II and Phase III studies. However, the estimated glomerular filtration rate (eGFR) endpoint was not achieved, partially attributed to disease heterogeneity among participants. Sparsentan reversed the molecular fingerprint in kidneys of an adriamycin-challenged rat model of chronic kidney disease, consistent with the phenotypic data.

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Objective: This study aimed to examine relationships of the degree and level of spinal ankylosis with spinal mobility and functional impairment in patients with radiographic axial spondyloarthritis (r-axSpA) using computed tomography (CT).

Methods: This retrospective study involving 27 patients examined the number of fused intervertebral segments in the whole, cervical, thoracic, and lumbar spine using CT as a measure of spinal ankylosis, Bath Ankylosing Spondylitis Metrology Index (BASMI) as a measure of spinal mobility, and Bath Ankylosing Spondylitis Functional Index (BASFI) as a measure of functional impairment.

Results: Significant positive correlations were found between both BASMI and BASFI and the number of fused intervertebral segments in the whole, cervical, thoracic, and lumbar spine.

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Background: Endoscopic unilateral laminectomy for bilateral decompression (ULBD) is gaining attention as a minimally invasive procedure for treating spinal stenosis. However, comprehensive studies on its outcomes remain limited.

Purpose: This study aims to evaluate the changes in radiologic parameters and clinical outcomes associated with endoscopic ULBD for treating spinal stenosis.

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