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Enzyme-assisted Rosa davurica mitigates UV-induced skin photodamage by modulating apoptosis through Nrf2/ARE and MAPK/NF-κB pathways.
J Photochem Photobiol B
January 2025
Graduate School of Biotechnology, Kyung Hee University, 1732 Deogyeong-daero, Giheung, Yongin 17104, Republic of Korea. Electronic address:
Exposure to UV irradiation results in abnormal, extensive apoptosis of skin cells. This excessive cell death can promote inflammation and alter the microenvironment, increasing the risk of skin cancer. Despite extensive research, few materials are effective at simultaneously protecting against both UVA and UVB irradiation.
View Article and Find Full Text PDFProgesterone receptors regulate susceptibility to spreading depression.
Exp Neurol
January 2025
Department of Neurology, University of Virginia, Charlottesville, VA 22908, USA; Department of Neuroscience, University of Virginia, Charlottesville, VA 22908, USA; UVA Brain Institute, University of Virginia, Charlottesville, VA 22908, USA.
Migraine patients often experience sensory symptoms called auras accompanying the headaches. Cortical spreading depression (CSD), a slow-propagating wave of neuroglial depolarization followed by hyperpolarization is proposed to be the neurological mechanism underlying these auras. We have previously found that progesterone regulates susceptibility to migraine through progesterone receptor (PR) activation.
View Article and Find Full Text PDFResveratrol polysaccharide is less cytotoxicity and inhibits UVA-, UVB-, and tertiary-butyl hydroperoxide-induced injury in human keratinocytes.
Naunyn Schmiedebergs Arch Pharmacol
January 2025
Meisterbio Co., Ltd., Okayama, Japan.
Natural stilbene compounds, such as resveratrol and pterostilbene, have been focused on owing to their diverse biological activities associated with antioxidant, anti-inflammatory, and anti-aging properties. However, their low water solubility limits their advanced applications. In this study, we investigated the protective effects of selected stilbene compounds (resveratrol, oxyresveratrol, gnetol, piceatannol, and pterostilbene) and their water-soluble derivatives (piceid, resveratrol polysaccharide, pterostilbene trisaccharide, and pterostilbene polysaccharide) against UVA-, UVB irradiation, tertiary-butyl hydroperoxide (t-BuOOH)- and hydrogen peroxide (HO)-induced injury in human epidermal cells.
View Article and Find Full Text PDFIdentifying ENO1 as a protein target of chlorogenic acid to inhibit cellular senescence and prevent skin photoaging in mice.
Aging Cell
December 2024
State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Artemisinin Research Center, and Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.
Cellular senescence plays a critical role in repeated ultraviolet (UV) exposure-induced skin photoaging. Currently, from the perspective of regulating senescent cells, potent compounds or reliable protein targets that could effectively prevent skin photoaging have not yet been reported. Herein, we demonstrated that chlorogenic acid (CGA) significantly inhibited UVA-induced senescence of human dermis skin fibroblasts (HDF) cells by screening the natural product library.
View Article and Find Full Text PDFComparison of Microalgae and Lipid Extracts Effects on UVA-Induced Changes in Human Skin Fibroblasts Proteome.
Mar Drugs
November 2024
Department of Analytical Chemistry, Medical University of Bialystok, Mickiewicza 2D, 15-222 Bialystok, Poland.
Article Synopsis
- - Lipid extracts from microalgae show promise in preventing UVA-induced metabolic disorders by maintaining redox balance and reducing inflammation in skin fibroblasts.
- - These extracts reverse the antioxidant suppression caused by UVA radiation and influence key molecular interactions that promote cytoprotection and reduce inflammation.
- - Their potential applications in cosmetics or cosmeceuticals to protect skin from UV damage indicate a need for further in vivo and clinical studies to evaluate efficacy.
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