[Effect of Klebsiella Pneumoniae bacterial colonization of the gastrointestinal tract on the immune processes in mice after weaning].

The influence of intestinal colonization by the Klebsiella pneumonia strain 50/59 on the characteristics of local and humoral immunity has been studied on CBA mice after weaning. Bacteria have been introduced intragastrally in doses of 1 x 10(6) bacteria per mice. Observations have been performed in dynamics during 11 days. They have shown that intestinal colonization induces significant elevation of the concentration of IgA in serum, intestinal content and percentage of splenocytes, expressing receptors of IgA, IgM, CD4 on the 7th day. On the 11th day a significant decrease in these parameters was observed. A conclusion is made that intestinal colonization is not indifferent for the whole organism and induces complex influences on its immune system.