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Lebanese Cannabis sativa L. extract protects from cisplatin-induced nephrotoxicity in mice by inhibiting podocytes apoptosis.
J Cannabis Res
January 2025
School of Pharmacy, Pharmaceutical Sciences Department, Lebanese American University, Byblos, Lebanon.
Background: Cisplatin is an anti-cancer drug used to treat a plethora of solid tumors. However, it is associated with dose dependent nephrotoxicity limiting its use as anticancer agent.
Objective: The current study aimed to investigate the nephroprotective effect of native Lebanese Cannabis sativa in both in vitro and in vivo mice model of cisplatin-induced nephrotoxicity.
Lebanese cannabis oil extract protected against folic acid-induced kidney fibrosis in rats.
PLoS One
December 2024
Pharmaceutical Sciences Department, School of Pharmacy, Lebanese American University, Byblos, Lebanon.
Article Synopsis
- Renal fibrosis is a significant issue in chronic kidney disease, with no existing treatments available to reverse it; the study explores the effects of Lebanese cannabis oil extract (COE) on renal injury induced by folic acid.
- Rats were administered folic acid to induce renal fibrosis, followed by varying doses of COE; results showed that COE improved kidney function by decreasing serum creatinine levels and alleviating associated renal and cardiac damage.
- In vitro tests demonstrated COE's ability to enhance podocyte cell viability and migration while also affecting key signaling pathways, suggesting potential therapeutic benefits of COE for kidney health.
Establishment of primary and immortalized fibroblasts reveals resistance to cytotoxic agents and loss of necroptosis-inducing ability in long-lived Damaraland mole-rats.
Geroscience
December 2024
Department of Aging and Longevity Research, Kumamoto University, 2-2-1 Honjo, Chuo-Ku, Kumamoto, 860-0811, Japan.
The Damaraland mole-rat (DMR; Fukomys damarensis) is a long-lived (~ 20 years) Bathyergid rodent that diverged 26 million years ago from its close relative, the naked mole-rat (NMR). While the properties of NMR cultured fibroblasts have been extensively studied and have revealed several unusual features of this cancer-resistant, long-lived species, comparative DMR studies are extremely limited. We optimized conditions for successfully culturing primary DMR skin fibroblasts and also established immortalized DMR cells using simian virus 40 early region expression.
View Article and Find Full Text PDFA 3D Bioprinting Approach to Studying Retinal Müller Cells.
Genes (Basel)
October 2024
Department of Biotechnological and Applied Clinical Sciences (DISCAB), University of L'Aquila, 67100 L'Aquila, Italy.
Bioprinting is an innovative technology in tissue engineering, enabling the creation of complex biological structures. This study aims to develop a three-dimensional (3D) bioprinted model of Müller cells (MCs) to enhance our understanding of their physiological and pathological roles in the retina. : We investigated two different hydrogels for their ability to support the viability and differentiation of rMC-1 cells, an immortalized retinal cell line.
View Article and Find Full Text PDFLrp1 facilitates infection of neurons by Jamestown Canyon virus.
bioRxiv
November 2024
Center for Vaccine Research, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.
Article Synopsis
- Jamestown Canyon virus (JCV) is a type of bunyavirus that causes neuroinvasive diseases in the U.S., but its mechanism of infection is not well understood.
- Recent research identifies low-density lipoprotein receptor related protein 1 (Lrp1) as a key factor that enables JCV and other bunyaviruses to infect cells, particularly in the nervous system.
- Experiments show that neurons lacking Lrp1 have reduced JCV infection rates, suggesting that targeting Lrp1 could lead to new antiviral treatments for diseases caused by bunyaviruses.
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