AI Article Synopsis
- Researchers conducted genetic linkage analysis on chromosome 10 to investigate inherited cancer syndromes like MEN2A and MEN2B using fifteen genetic markers.
- A new polymorphic microsatellite at the D10S141 locus was identified as a recombinant marker for both MEN2A and MEN2B, helping to pinpoint the MEN2A gene's location.
- The study also established D10S94 as the closest distal marker for MEN2A, clarifying the region's genetic context and indicating MEN2B gene mapping to a larger area.
Article Abstract
We have carried out genetic linkage analyses using fifteen polymorphic loci in the pericentromeric region of chromosome 10 in families with the inherited cancer syndromes multiple endocrine neoplasia (MEN) type 2A or 2B. A highly polymorphic microsatellite from the locus D10S141 in q11.2 was found to be recombinant with respect to the disease locus in two individuals and defines a new proximal flanking marker for both MEN2A and 2B. An additional recombination provides evidence that the locus D10S94, also in q11.2, is the closet distal flanking marker for MEN2A. This localises the MEN2A gene to a small region of 10q11.2 flanked by the loci D10S141 and D10S94, which are separated by a sex-averaged genetic distance of 0.55 cM. The MEN2B gene maps to a larger region, flanked by D10S141 and RBP3.
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| http://dx.doi.org/10.1093/hmg/2.3.241 | DOI Listing |
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