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Burden of human rabies disease: its potential prevention by means of Rabipur vaccine.
J Prev Med Hyg
September 2024
Department of Health Sciences (DISSAL), University of Genoa, Genoa, Italy.
Rabies is a zoonotic viral disease transmitted mainly by bites of infected animals, especially dogs, which are responsible for 99% of human cases. Despite being preventable, it remains a neglected disease in low-income countries, with approximately 60,000 deaths per year, mostly concentrated in Africa and Asia. The real worldwide burden of rabies is probably underestimated, as death-reporting systems are inadequate and active surveillance is limited.
View Article and Find Full Text PDFEvaluation of the immune status of dogs vaccinated against rabies by an enzyme-linked immunosorbent assay using crude preparations of insect cells infected with a recombinant baculovirus encoding the rabies virus glycoprotein gene.
PLoS One
December 2024
KVAFSU-CVA Rabies Diagnostic Laboratory, Department of Veterinary Microbiology, Veterinary College, Karnataka Veterinary Animal and Fisheries Sciences University, Bengaluru, India.
Article Synopsis
- * ELISA has been suggested as an easier alternative but struggles with antigen availability, particularly RABV glycoprotein, which requires high biosafety levels for use.
- * The research tested insect cell extracts producing RABV glycoprotein and found it effectively detected rabies antibodies in vaccinated dogs, with a 90.48% sensitivity and 80.00% specificity, making it suitable for quick screening and monitoring vaccination efforts.
Estimates of the burden of human rabies deaths and animal bites in India, 2022-23: a community-based cross-sectional survey and probability decision-tree modelling study.
Lancet Infect Dis
January 2025
Indian Council of Medical Research (ICMR)-National Institute of Epidemiology, Chennai, India. Electronic address:
Article Synopsis
- - The study investigates the prevalence of dog bites and human rabies deaths in India, where a significant portion of global rabies cases occurs, aiming to assess progress toward a 2030 elimination goal.
- - A nationwide survey found that in a year, there were approximately 9.1 million dog bites in India, with 20.5% of those bitten not receiving necessary anti-rabies vaccinations (ARV).
- - The study estimates around 5,726 human rabies deaths annually, indicating that, despite some progress, there's still a critical need for improved vaccination and prevention strategies.
Characterization and treatment protocol of injuries inflicted to humans by synurbic European wild boars (Sus scrofa).
Eur J Trauma Emerg Surg
October 2024
Servei d'Ecopatologia de Fauna Salvatge (SEFaS) and Wildlife Ecology & Health Group (WE&H), Medicine and Surgery Animal Department, Universitat Autònoma de Barcelona, Barcelona, Spain.
Article Synopsis
- This study investigates injuries caused by wild boar encounters in urban areas, focusing on a systematic literature review and the creation of a wound management protocol.
- A total of 14 relevant studies were reviewed, and data from 34 patients treated for wild boar injuries between 2020-2022 was analyzed, revealing that most injuries were superficial, primarily occurring on the lower limbs.
- The proposed management protocol resulted in a low complication rate, with recommendations for specific treatments including antibiotics, tetanus vaccinations, and individualized care plans based on injury type.
Profile and Geospatial Analysis of Dog Bite Cases Attending the Antirabies Vaccine Outpatient Department at the Tertiary Level Hospital of Mumbai.
Indian J Public Health
April 2024
Professor and Head, Department of Community Medicine, Grant Government Medical College and Sir JJ Group of Hospitals, Mumbai, Maharashtra, India.
Background: Dog bites pose a significant public health concern in India, necessitating an understanding of their epidemiological profile and spatial distribution. Adopting the One Health approach, which considers the interconnection of human, animal, and environmental health, is vital for developing effective interventions.
Objectives: The study aimed to assess the epidemiological profile and geospatial trends of dog bite cases in an urban area, focusing on the age and gender distribution of victims, severity of bites, and spatial distribution of cases to inform prevention strategies.
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