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Effects of Food on the Pharmacokinetics and Safety of HA121-28 Tablet, a Novel Multi-Targeting Tyrosine Kinase Inhibitor, in Healthy Chinese Subjects: A Phase I Clinical Trial.
Drug Des Devel Ther
January 2025
Cancer Center, West China Hospital, Sichuan University, Chengdu, 610041, People's Republic of China.
Purpose: HA121-28, a novel multi-targeting tyrosine kinase inhibitor, has dual efficacy against tumor growth and neovascularization. The objectives of this study were to assess the effect of high-fat and high-calorie food on the pharmacokinetic (PK) profile and safety of HA121-28 tablet in healthy subjects.
Patients And Methods: A single-dose, randomized, open-label, two-period, crossover-designed phase I clinical trial was conducted.
A very low carbohydrate diet improved metabolic profile in congenital generalized lipodystrophy type 4.
Endocrinol Diabetes Metab Case Rep
January 2025
Summary: A 17-year-old girl presented with recurrent attacks of acute pancreatitis, associated with severe hyperglycemia and hypertriglyceridemia, despite being on intensive insulin therapy for the last 10 years. She had severe acanthosis nigricans, generalized loss of subcutaneous fat and prominent veins over extremities. The serum levels of glucose and triglyceride did not reduce significantly, even with maximally tolerated doses of metformin (2 g), pioglitazone (45 mg) and fenofibrate (160 mg), not uncommonly seen in poor rural families in West Bengal, India.
View Article and Find Full Text PDFLongitudinal Associations of PFAS Exposure With Insulin Sensitivity and β-Cell Function Among Hispanic Women With Gestational Diabetes Mellitus History.
Diabetes Care
January 2025
Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA.
Objective: We investigated associations between per- and polyfluoroalkyl substances (PFAS) and changes in diabetes indicators from pregnancy to 12 years after delivery among women with a history of gestational diabetes mellitus (GDM).
Research Design And Methods: Eighty Hispanic women with GDM history were followed from the third trimester of pregnancy to 12 years after delivery. Oral and intravenous glucose tolerance tests were conducted during follow-up.
Physicochemical and Microbiological Quality Assessment of Artisanal and Commercial Recipes of Cucurbita ficifolia Jams with High Sensory Acceptability.
Plant Foods Hum Nutr
January 2025
PRONOA Laboratory, CIITeD- CONICET Jujuy National University, Italo Palanca 10, San, Salvador de Jujuy, 4600, Argentina.
Artisanal cayote jam consumption is widespread in Latin-American countries. This jam is prepared from the pulp of Cucurbita ficifolia Bouché. Here, an artisanal cayote jam recipe and a reduced-calorie artisanal cayote jam recipe were defined through sensory analysis.
View Article and Find Full Text PDFThe effect of a comprehensive intervention on anthropometric indices, dietary intake, and physical activity of adolescent boys with overweight.
BMC Pediatr
January 2025
Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Background: Non-communicable diseases in adulthood are reported to be strongly associated with adolescent obesity. The present study aimed to assess the effect of a comprehensive lifestyle modification intervention on the anthropometric indices, dietary intake, and physical activity of adolescent boys with overweight.
Methods: This pragmatic trial was conducted on 126 adolescent boys with overweight.
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