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A Novel Multiepitope Fusion Antigen as a Vaccine Candidate for the Prevention of Enterotoxigenic -Induced Calf Diarrhea.
Vaccines (Basel)
April 2024
National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, China.
Calf diarrhea caused by enterotoxigenic (ETEC) poses an enormous economic challenge in the cattle industry. Fimbriae and enterotoxin are crucial virulence factors and vaccine targets of ETEC. Since these proteins have complicated components with large molecular masses, the development of vaccines by directly expressing these potential targets is cumbersome Therefore, this study aimed to develop a multiepitope fusion antigen designated as MEFA by integrating major epitopes of FanC and Fim41a subunits and a toxoid epitope of STa into the F17G framework.
View Article and Find Full Text PDFmiR-329b-5p Affects Sheep Intestinal Epithelial Cells against F17 Infection.
Vet Sci
May 2024
College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China.
Diarrhea is the most common issue in sheep farms, typically due to pathogenic () infections, such as F17. microRNA, a primary type of non-coding RNA, has been shown to be involved in diarrhea caused by pathogenic . To elucidate the profound mechanisms of miRNA in F17 infections, methods such as F17 adhesion assay, colony counting assay, relative quantification of bacterial fimbriae gene expression, indirect immune fluorescence (IF), Cell Counting Kit-8 (CCK-8), 5-ethynyl-2'-deoxyuridine (EdU), Western blotting (WB), and scratch assay were conducted to investigate the effect of miR-329b-5p overexpression/knock-down on F17 susceptibility of sheep intestinal epithelial cells (IECs).
View Article and Find Full Text PDFDevelopment of a bispecific Nanobody anti-F17 fimbria as a potential therapeutic tool.
Protein Expr Purif
March 2024
Livestock and Wildlife Laboratory (LR16IRA04), Arid Lands Institute (I.R.A), University of Gabès, Médenine, 4119, Tunisia.
Pathogenic strains of Escherichia coli F17+ are associated with various intestinal and extra-intestinal pathologies, including diarrhea, and result in significant animal mortality. These infections rely on the expression of virulence factors, such as F17 fimbriae, for adhesion. F17 fimbriae form a protective layer on the surface of E.
View Article and Find Full Text PDFThe transmutation of Escherichia coli ATCC 25922 to small colony variants (SCVs) E. coli strain as a result of exposure to gentamicin.
J Infect Public Health
November 2023
Microbiology Department, King Fahd Medical City, Riyadh, Saudi Arabia.
Background: Small colony variants (SCVs) are biotypes of bacteria that have a size of approximately one-tenth or less of the wild types and has distinct characteristics comparing to the wild type strains. Clinical SCVs are usually associated with persistent infection and require a long-term treatment program with antibiotics. In Saudi Arabia, there are few studies about SCVs Escherichia coli for this reason, this study is aimed to investigate the ability of gentamicin to mutate E.
View Article and Find Full Text PDFPrevalence of neonatal calf diarrhea caused by Escherichia coli and investigation of virulence factors, serotypes, and antibiotic susceptibility.
Pol J Vet Sci
September 2023
Department of Microbiology, Faculty of Veterinary Medicine, Kyrgyz-Turkish Manas University, 720038, Bishkek, Kyrgyzstan.
Neonatal calf diarrhea (NCD) is one of the most important concerns in cattle production. Escherichia coli is the most important bacterial agent of NCD. Although vaccination and antibiotic treatment are common in NCD, the high antigenic diversity of E.
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