AI Article Synopsis
- A 5' flanking region of the guinea pig liver transglutaminase gene was successfully cloned and sequenced.
- The analysis revealed the presence of a TATA box and potential binding sites for several regulatory factors.
- The promoter activity of this region was confirmed through experiments involving transfection into human hepatoblastoma HepG2 cells using a fusion-construct with the chloramphenicol acetyltransferase gene.
Article Abstract
A 5' flanking region of the guinea pig liver transglutaminase gene was cloned and sequenced. The sequences for TATA box and potential binding sites of some regulatory factors were found in this region. The promoter activity of this region was shown by transfecting its fusion-construct with the chloramphenicol acetyltransferase gene into human hepatoblastoma HepG2 cells.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/0167-4781(93)90221-x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Prevalence and factors associated with neonatal sepsis in Mali: a cross-sectional study.
BMJ Open
January 2025
USTTB FMOS, Bamako, Mali.
Objective: This study aimed to assess the prevalence and risk factors for neonatal sepsis among neonates admitted to selected health facilities in the Bamako district and Koulikoro region in Mali.
Design: This is a prospective cross-sectional study. Data were analyses using bivariate and multivariate logistic regression.
Neurosteroid replacement therapy using tiagabine and zuranolone restores cerebellar neurodevelopment and reduces hyperactive behaviour following preterm birth.
J Dev Orig Health Dis
January 2025
School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, Australia.
Preterm birth exposes the neonate to hypoxic-ischaemic and excitotoxic insults that impair neurodevelopment and are magnified by the premature loss of placentally supplied, inhibitory neurosteroids. The cerebellum is a neuronally dense brain region, which undergoes critical periods of development during late gestation, when preterm births frequently occur. We propose that neurosteroid replacement therapy using tiagabine and zuranolone will protect the cerebellum against preterm-associated insults.
View Article and Find Full Text PDFThe potential of bone marrow derived mesenchymal stem cells in treating cisplatin induced sensorineural hearing loss in a guinea pig animal model.
Tissue Cell
December 2024
ENT Department, Faculty of Medicine, Suez Canal University, Ismailia, Egypt. Electronic address:
Background: Sensorineural hearing loss (SNHL) is the most common sensory deficit worldwide. Current solutions for SNHL, including hearing aids, cochlear implants, and hearing assistive devices, do not provide consistent results and fail to address the underlying pathology of hair cell and ganglion cell damage. Stem cell therapy is a cornerstone in regenerative medicine.
View Article and Find Full Text PDFGenomic and epidemiological analysis of SARS-CoV-2 variants isolated in Guinea: a routine sequencing implementation.
BMC Infect Dis
January 2025
Centre de Recherche et de Formation en Infectiologie de Guinée (CERFIG), Université Gamal Abder Nasser de Conakry, Conakry, Guinea.
Background: Several variants of SARS-CoV-2 have a demonstrated impact on public health, including high and increased transmissibility, severity of infection, and immune escape. Therefore, this study aimed to determine the SARS-CoV-2 lineages and better characterize the dynamics of the pandemic during the different waves in Guinea.
Methods: Whole genome sequencing of 363 samples with PCR cycle threshold (Ct) values under thirty was undertaken between May 2020 and May 2023.
Tuberculosis screening among cough suppressant buyers in pharmacies and drug outlets in Guinea: a cross-sectional study.
BMJ Open Respir Res
December 2024
World Health Organization, Geneva, Switzerland.
Article Synopsis
- Tuberculosis (TB) is a major health issue in Guinea, with many cases going undetected; an intensified case finding strategy involved pharmacies and drug outlets targeting customers buying cough suppressants.
- A study conducted in Conakry involved screening 916 individuals for TB, resulting in a 14% bacteriologically confirmed TB diagnosis, with gender and age influencing diagnosis likelihood.
- The intervention cost approximately $32.66 per person referred and $237.45 for those diagnosed, showing that using pharmacies as a TB detection point is both feasible and effective in boosting detection rates.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!