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Enlightening the promising role of nanoparticle-based treatments against Naegleria fowleri-induced primary amoebic meningoencephalitis: A brain-eating disease.
Microb Pathog
December 2024
Diamond Harbour Women's University, Department of Zoology, Sarisha, West Bengal, 743368, India. Electronic address:
Naegleria fowleri, is the causative agent of Primary Amoebic Meningoencephalitis (PAM), a lethal acute brain inflammation with high mortality. The virulent and reproductively active trophozoite stage of N. fowleri migrates to central nervous system (CNS) by entering through nasal passage and causes severe neural infection, brain disease and inflammation with high mortality.
View Article and Find Full Text PDFStudy of Neuroinflammation in the Rat Hippocampus during Ethanol Exposure and Pharmacological Correction with Azithromycin: New Data and Future Perspectives.
Biochemistry (Mosc)
November 2024
Institute of Experimental Medicine, St. Petersburg, 197376, Russia.
With prolonged ethanol ingestion, disturbances in the emotional spectrum develop, and memory problems are noted. These symptoms could be mediated by the development of neurochemical changes in the hippocampus of the brain. Although there is evidence that hippocampus is vulnerable to chronic alcohol intoxication and that neuroinflammation and neurodegeneration develop in this brain region, the key molecular mechanisms have not been identified.
View Article and Find Full Text PDFPerinatal Caffeine Administration Improves Outcomes in an Ovine Model of Neonatal Hypoxia-Ischemia.
Stroke
November 2024
Department of Pediatrics (J.K.M., Y.W., J.H., A.I., C.H., R.S.H., C.V., H.M., J.L.-B., J.R.F., D.M.F., E.M.), University of California San Francisco.
Article Synopsis
- Neonatal hypoxic-ischemic encephalopathy primarily impacts low- and middle-income countries, with therapeutic hypothermia often proving ineffective, highlighting a need for earlier treatment strategies.
- A study involved administering perinatal caffeine to near-term lambs undergoing severe hypoxia-ischemia, assessing its pharmacokinetics, safety, and efficacy in improving outcomes.
- Caffeine administration enhanced neurodevelopmental results and decreased inflammation and gray matter damage, suggesting it could be a viable treatment for affected neonates compared to previous studies on other medications.
Cerebral Venous Sinus Thrombosis Following Scrub Typhus Meningoencephalitis in a Pregnant Woman.
Neurohospitalist
October 2024
Department of Neurology, University Hospital "12 de Octubre", Madrid, Spain.
Article Synopsis
- Scrub typhus is a disease caused by mites and is common in the Asia Pacific, leading to serious neurological problems like meningoencephalitis and, in rare cases, CVST.
- A unique case involved an 18-year-old pregnant woman in India who, after experiencing symptoms like fever and headaches, was found to have CVST stemming from scrub typhus meningoencephalitis; treatment involved azithromycin and later anticoagulation therapy.
- The report emphasizes the need to consider CVST in pregnant women with severe scrub typhus symptoms even if antibiotics are being used, as early treatment is crucial for better outcomes.
Macrolide resistance outcomes after the Covid-19 pandemic: A one health approach investigation.
Biomed Pharmacother
November 2024
Department of Health and Biological Sciences, Pontifical Catholic University, Minas Gerais, Brazil. Electronic address:
Article Synopsis
- The widespread and unprescribed use of macrolide antibiotics during the Covid-19 pandemic in Brazil was driven by a lack of scientific knowledge among the population.
- Samples of Staphylococcus bacteria were collected from hospital environments to study resistance genes linked to these antibiotics, particularly in urinary tract infections.
- The research examined the broader implications of antibiotic misuse on community health, the environment, and connections between physiological and immunological factors, emphasizing the importance of a One Health approach.
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