AI Article Synopsis
- Clinical evaluation and advanced imaging techniques were used to study stomach mucosa in both control subjects and habitual tobacco chewers.
- Significant electron microscopic changes were observed in the gastric mucosa of tobacco chewers, indicative of potential damage or irregularities.
- The findings suggest that long-term tobacco chewing may lead to changes in the stomach lining that could increase the risk of stomach cancer.
Article Abstract
Clinical evaluation, upper gastrointestinal endoscopy and electron microscopy of mucosal biopsies from antrum, body and fundus of stomach were performed in three control subjects and 17 habitual tobacco chewers. Electron microscopic abnormalities such as discontinuous, fragmented basement membrane with reduction in hemidesmosomes, and widened intercellular spaces filled with clusters of desmosomes were found in the gastric mucosa of habitual tobacco chewers; these were similar to those reported in experimental carcinogenesis and leukoplakia. It is concluded that habitual chewing of tobacco produces electron microscopic alterations in the human gastric mucosa which may be important precursors for gastric malignancy.
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