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- The obligate intracellular parasite replicates within a compartment called the parasitophorous vacuole (PV) and utilizes a protein ingestion pathway to take in nutrients from the host cell's cytosol, initiated by the protein GRA14.
- A genome-wide CRISPR screen revealed that mutants lacking components of this ingestion pathway (GRA14, CPL, or CRT) are forced to rely more on alternative metabolic pathways to survive, such as pyrimidine and fatty acid biosynthesis.
- Analysis showed that these ingestion-deficient mutants had lower levels of key nutrients and growth defects when amino acids were scarce, indicating that the ingestion pathway plays a crucial role in nutrient acquisition during resource-limited conditions.
Diverse clinical manifestations of acquired vulvar lymphangioma: a report of five cases in Vietnamese women.
Dermatol Reports
September 2024
Ho Chi Minh City Hospital of Dermato-Venereology, Ho Chi Minh City.
Acquired vulvar lymphangioma (AVL) is a rare but important condition that requires prompt diagnosis and appropriate management to alleviate symptoms and prevent complications. AVL can erupt locally as isolated or clustered lesions which range from translucent, fluid-filled vesicles to smooth, flesh-colored papules or nodules that exude serous or crystalline liquid spontaneously or after trauma. Clinically, it can also be asymptomatic.
View Article and Find Full Text PDFProteomics of circulating extracellular vesicles reveals diverse clinical presentations of COVID-19 but fails to identify viral peptides.
Front Cell Infect Microbiol
November 2024
ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain.
Article Synopsis
- Extracellular vesicles (EVs) from virus-infected cells could aid in vaccine development by encapsulating viral peptides and indicating tissue changes in infections.
- Blood samples from severe COVID-19 patients, mild cases, and uninfected healthcare workers were collected to analyze the molecular characteristics of EVs and identify suitable vaccine peptides.
- Despite the expectation to find viral peptides, the proteomic analysis revealed no such findings, but highlighted a diverse EV cargo linked to inflammation and viral replication, suggesting EVs play a significant role in COVID-19 pathology.
Circulating extracellular vesicles in sera of chronic patients as a method for determining active parasitism in Chagas disease.
PLoS Negl Trop Dis
November 2024
Department of Parasitology, Biochemical and Molecular Parasitology Group CTS-183, and Institute of Biotechnology, University of Granada., Granada, Spain.
Background: Chagas disease, once restricted mainly to the Americas, Chagas disease has become a global health problem due to migration from endemic to non-endemic areas. In non-endemic regions, transmission is limited to vertical transmission from infected mothers to newborns or through blood and organ donations. A major challenge in the management of the disease lies in the diagnosis of chronic cases, as blood-borne parasites are often absent and antibodies persist for life, complicating the evaluation of treatment.
View Article and Find Full Text PDFGenital Herpes: Rapid Evidence Review.
Am Fam Physician
November 2024
Eglin Air Force Base Family Medicine Residency Program in Florida.
Article Synopsis
- - Genital herpes, caused by herpes simplex virus (HSV) types 1 or 2, is a lifelong sexually transmitted infection affecting over 500 million people globally, with no available vaccines for prevention.
- - It is characterized by painful genital lesions and flu-like symptoms; diagnosis is typically made through laboratory tests like PCR or viral culture.
- - Treatment includes antiviral medications to manage outbreaks and reduce transmission, and pregnant individuals with a history of genital herpes are advised to start antiviral therapy at 36 weeks and may require a cesarean section if lesions are present.
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