Stearly tyrosine has been described in the literature as a candidate adjuvant for human vaccines. More recently, other stearyl esters have been reported to be adjuvant-active. This preliminary study assesses the adjuvanticity of stearyl amides, including the amide analogue of stearyl tyrosine: tyrosyl stearylamine. This study indicates that phenylalanylethanolamine O-stearate induces a significant antibody response and a favourable isotype distribution.
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Further studies on the adjuvanticity of stearyl tyrosine and amide analogues.
Vaccine
May 1994
BioChem Therapeutic Inc., Laval, Québec, Canada.
Stearly tyrosine has been described in the literature as a candidate adjuvant for human vaccines. More recently, other stearyl esters have been reported to be adjuvant-active. This preliminary study assesses the adjuvanticity of stearyl amides, including the amide analogue of stearyl tyrosine: tyrosyl stearylamine.
View Article and Find Full Text PDFFurther studies on the adjuvanticity of stearyl tyrosine and ester analogues.
Vaccine
January 1994
Immunomodulator Research, BioChem Pharma Inc., Laval, Quebec, Canada.
A new family of immunoadjuvants, long-chain stearyl esters of amino acids and peptides, are described and examined with bacterial and viral vaccines. The parent compound, stearyl tyrosine, displayed significant adjuvant activity with these vaccines. Stearyl glycyl glycine displayed superior activity with viral vaccines.
View Article and Find Full Text PDFAdjuvanticity of stearyl tyrosine on the antibody response to peptide 503-535 from HIV gp160.
AIDS Res Hum Retroviruses
August 1992
Department of Microbiology, Mount Sinai School of Medicine, New York, NY 10029.
Adjuvanticity of stearyl tyrosine on the antibody response to peptide 503-535 from HIV gp160.
Viral Immunol
July 1992
Department of Microbiology, Mount Sinai School of Medicine, New York, New York.
In this present report we compare the humoral immune response induced by immunization with an HIV-1 gp160 peptide corresponding to amino acid sequence 503-535 complexed with different adjuvants. Specifically, the antipeptide, anti-HIV-1 gp160 and neutralizing antibody responses were measured in groups of mice and baboons that received peptide 503-535 conjugated to a carrier protein in either saline, alum, or stearyl tyrosine. The highest antibody responses were induced when mice and baboons were immunized with peptide adsorbed on stearyl tyrosine.
View Article and Find Full Text PDFPreliminary studies of some of the properties of stearyl tyrosine have shown that it is non-toxic, free of adverse reactions at the sites of injection, non-pyrogenic, stable upon storage and easy to sterilize. Formalin inactivated poliovirus vaccine (IPV) adjuvanted with stearyl tyrosine hydrochloride induced significantly higher titres of antibodies in non-human primates, after two injections, than the non-adjuvanted vaccine. Furthermore, the adjuvanted vaccine, even when diluted 1:4, showed consistently higher antibody titres as well as a longer persistence of antibodies than the non-adjuvanted undiluted vaccine.
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