[Relationship between blood fibrinogen and plasma lipoproteins in patients with hypercholesterolemia].

Objective: Subjects with risk factors of atherosclerotic cardiovascular disease showed frequently high plasma levels of fibrinogen. Nevertheless, the relationship between hyperfibrinogenemia and atherosclerotic risk factors is not yet well known. In particular, some studies showed a correlation between hyperlipoproteinemia and high plasma levels of fibrinogen, even if the mechanism(s) involved in the hyperfibrinogenemia associated with hyperlipoproteinemia is not completely clear.

Study Design And Subjects: In this retrospective study on 139 out-patients, affected by hyperlipoproteinemia type II, the relationship between fibrinogen plasma levels and some lipid parameters, such as total cholesterol (CT), triglycerides, LDL-cholesterol, HDL-cholesterol (HDL-C), lipoprotein (a), apolipoproteins (Apo) A-I and B was evaluated.

Results: Fibrinogen plasma levels showed a significant inverse correlation with HDL-C (r = -0.25), HDL-C/CT (Rho = -0.22), Apo A-I (r = -0.33) serum concentration and a direct significant correlation with triglycerides serum levels (r = 0.22). Multiple stepwise regression analysis confirms the independence of association between Apo A-I and fibrinogen plasma levels.

Conclusion: In patients with type II hyperlipoproteinemia, the increase of fibrinogen plasma levels seems to be related to the modification of serum concentration of specific lipoprotein, such as those rich in triglycerides and those with high density.