We took the unit discharges of the neurons in the posterior group of thalamic nuclei (PO) caused by stimulating the great splanchnic nerve (GSN) as an indicator of visceral pain. We searched for the effects of electrical stimulating central nucleus of amygdala (AC), lateral nucleus of amygdala (AL), bed nucleus of striae terminalis (BNST) and lateral area of hypothalmus (AHL) on unit discharges of PO and the relationship among these nucleuses. The result indicated that the inhibitory effects were strongest with stimulating AC, the next was with stimulating AHL, then BNST and AL. The inhibitory percentages were 85.7% (AC), 62.9% (AHL), 53.1% (BNST) and 54.2% (AL) respectively. The inhibitory effects of stimulating AC couldn't be canceled by injecting naloxone intravenously. AC may be more important for the antinociceptive system than AL, BNST and AHL. There was no relationship between AC and BNST on the inhibition of unit discharges. The inhibitory effects of stimulating AL may be related to AC.
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Brain
March 2025
Krembil Brain Institute, University Health Network, Toronto, ON M5T 1M8, Canada.
Parkinson's disease is characterized, in part, by hypoactivity of direct pathway inhibitory projections from striatum to the globus pallidus internus (GPi) and indirect pathway inhibitory projections from globus pallidus externus (GPe) to the subthalamic nucleus (STN). In people with Parkinson's disease (n=32), we explored the potential use of intracranial stimulation for eliciting long-term potentiation (LTP) of these underactive pathways to produce improvement of symptoms that persists beyond stimulation cessation. During GPi deep brain stimulation (DBS) surgery, we found strong evidence (p<.
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Universidade Federal do Piauí, Programa de Pós-Graduação em Odontologia (PPGO), Teresina, Piauí, Brasil.
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School of Science and Technology, Nottingham Trent University, Nottingham, UK.
Novel treatment options are needed for the gastric pathogen due to its increasing antibiotic resistance. The vitamin K analogue menadione has been extensively studied due to interest in its anti-bacterial and anti-cancer properties. Here, we investigated the effects of menadione on growth, viability, antibiotic resistance, motility and gene expression using clinical isolates.
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Regenerative Medicine & Cellular Therapies Division, School of Pharmacy, The University of Nottingham Biodiscovery Institute (BDI), University of Nottingham, Nottingham, NG7 2RD, UK.
Topically applied therapies must not only be effective at the molecular level but also efficiently access the target site which can be on milli/centimetre-scales. This bottleneck is particularly inhibitory for peptide and nucleic acid macromolecule drug delivery strategies, especially when aiming to target wounded, infected, and poorly perfused tissues of significant volume and geometry. Methods to drive fluid-flow or to enhance physical distribution of such formulations after local administration in accessible tissues (skin, eye, intestine) would be transformative in realizing the potential of such therapeutics.
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March 2025
Division of Hematology and Blood Banking, Department of Laboratory Science, School of Paramedical Science, Shiraz University of Medical Science, Shiraz, Iran.
Burkitt lymphoma, a highly aggressive form of non-Hodgkin lymphoma, have significant treatment challenges, such as chemotherapy-related toxicity and the risk of relapse, especially in older adults. Treatment of Raji cells, a Burkitt lymphoma cell line, with parthenolide in combination to doxorubicin may enhance therapeutic efficacy. This study aimed to evaluate cell viability and apoptosis following treatment with these agents, and to investigate the underlying molecular mechanisms involving miR-27b and the MET/PI3K/AKT signaling pathway.
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