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Unveiling the Silent Crisis Amidst Tackling Hepatitis B in African Prisons - A Public Health Emergency.
Health Sci Rep
March 2025
Department of Veterinary Medicine, Faculty of Veterinary Medicine University of Ibadan Ibadan Nigeria.
Background: Hepatitis B is one of the major global health issues, which presents a particularly severe challenge within the confines of African prisons, characterized by high rates of transmission and limited access to adequate healthcare. The prevalence of Hepatitis B in these settings represents a silent crisis.
Objective: This research highlights the critical public health emergency posed by Hepatitis B in African prisons, underscoring the need for urgent intervention and comprehensive strategies.
A critical review of microbiome-derived metabolic functions and translational research in liver diseases.
Front Cell Infect Microbiol
March 2025
Human Cytogenetics and Stem Cell Laboratory, Department of Zoology, School of Basic Sciences, Central University of Punjab, Bathinda, Punjab, India.
Significant changes in gut microbial composition are associated with chronic liver disease. Using preclinical models, it has been demonstrated that ethanol/alcohol-induced liver disease is transmissible through fecal microbiota transplantation (FMT). So, the survival rate of people with severe alcoholic hepatitis got better, which suggests that changes in the makeup and function of gut microbiota play a role in metabolic liver disease.
View Article and Find Full Text PDFModeling Liver Fibrosis Progression in Patients With Viral Hepatitis Using the Machine Learning Tool Subtype and Stage Inference (SuStaIn).
Cureus
February 2025
Department of Radiology, Juntendo University Graduate School of Medicine, Tokyo, JPN.
Background and aim The natural progression of liver fibrosis and its association with biomarker changes have not been fully established in the literature. This study aimed to investigate liver fibrosis progression in patients with hepatitis B virus (HBV) and hepatitis C virus (HCV) infection using a novel machine learning tool called 'Subtype and Stage Inference (SuStaIn).' SuStaIn can identify disease progression patterns and subgroups from cross-sectional biomarker data.
View Article and Find Full Text PDFOptimizing Hepatocellular Carcinoma Screening: A Comparative Simulated Abbreviated MRI Protocol Study.
Cureus
February 2025
Department of Radiology, Krishna Institute of Medical Sciences, Secunderabad, IND.
Background Patients with risk factors such as viral hepatitis-induced liver cirrhosis, advanced-stage primary biliary cirrhosis, hereditary hemochromatosis, metabolic-associated fatty liver disease, and alcoholic liver disease are more likely to develop hepatocellular carcinoma (HCC). Most HCC patients have advanced-stage disease unresponsive to treatment. Therefore, avoiding or treating viral infections and early detection through routine surveillance, such as repeated liver ultrasonography, are the most effective ways to reduce HCC-related mortality.
View Article and Find Full Text PDFConundrum of Acute Liver Failure.
Ann Afr Med
March 2025
Department of General Medicine, Dr. Pinnamaneni Siddhartha Institute of Medical Sciences and Research Foundation, Krishna, Andhra Pradesh, India.
A 20-year-old male with fever, myalgia, and jaundice developed severe liver dysfunction, progressing to acute liver failure (ALF). Initial treatment for malaria and supportive care did not resolve symptoms, with persistent jaundice and elevated liver enzymes. Laboratory tests confirmed Plasmodium falciparum/Plasmodium vivax infection.
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