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Doxorubicin-Intercalated Li-Al-Based LDHs as Potential Drug Delivery Nanovehicle with pH-Responsive Therapeutic Cargo for Tumor Treatment.
ACS Biomater Sci Eng
October 2024
School of Materials Science and Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi 221005, India.
Clinical oncology is currently experiencing a technology bottleneck due to the expeditious evolution of therapy defiance in tumors. Although drugs used in chemotherapy work for a sort of cell death with potential clinical application, the effectiveness of chemotherapy-inducing drugs is subject to several endogenous conditions when used alone, necessitating the urgent need for controlled mechanisms. A tumor-targeted drug delivery therapy using Li-Al (M/M)-based layered double hydroxide (LDHs) family has been proposed with the general chemical formula [M M (OH)][(A).
View Article and Find Full Text PDFEndogenous Interfacial Mo-C/N-Mo-S Bonding Regulates the Active Mo Sites for Maximized Li Storage Areal Capacity.
Small
August 2024
College of Materials Science and Engineering, Hunan Joint International Laboratory of Advanced Materials and Technology for Clean Energy, Hunan University, Changsha, 410082, P. R. China.
Active sites, mass loading, and Li-ion diffusion coefficient are the benchmarks for boosting the areal capacity and storage capability of electrode materials for lithium-ion batteries. However, simultaneously modulating these criteria to achieve high areal capacity in LIBs remains challenging. Herein, MoS is considered as a suitable electroactive host material for reversible Li-ion storage and establish an endogenous multi-heterojunction strategy with interfacial Mo-C/N-Mo-S coordination bonding that enables the concurrent regulation of these benchmarks.
View Article and Find Full Text PDFAngiotensin-converting enzyme inhibitors and angiotensin-II-receptor antagonists modulate sodium handling based on endogenous lithium clearance.
Kardiol Pol
February 2024
Department of Internal Medicine and Gerontology, Jagiellonian University Medical College, Kraków, Poland.
Background: Numerous studies based on assessment of lithium clearance demonstrated higher sodium reabsorption in renal proximal tubules in individuals with hypertension, overweight, obesity, metabolic syndrome, or diabetes.
Aims: We aimed to assess the influence of angiotensin-converting enzyme inhibitors (ACE-I) or angiotensin-II-receptor antagonists (ARB) treatment on sodium handling.
Methods: In a sample of 351Caucasian subjects without diuretic treatment with prevailing sodium consumption, we studied associations between renal sodium reabsorption in proximal (FPRNa) and distal (FDRNa) tubules assessed by endogenous lithium clearance and daily sodium intake measured by 24-hour excretion of sodium (UNaV), in the context of obesity and long-term treatment with ACE-I or ARB.
The circadian clock time tunes axonal regeneration.
Cell Metab
December 2023
Division of Neuroscience, Department of Brain Sciences, Imperial College London, London W120NN, UK. Electronic address:
Nerve injuries cause permanent neurological disability due to limited axonal regeneration. Injury-dependent and -independent mechanisms have provided important insight into neuronal regeneration, however, common denominators underpinning regeneration remain elusive. A comparative analysis of transcriptomic datasets associated with neuronal regenerative ability revealed circadian rhythms as the most significantly enriched pathway.
View Article and Find Full Text PDFEndogenous NbCT/NbO Schottky heterostructures for superior lithium-ion storage.
J Colloid Interface Sci
December 2023
Key Laboratory for Photonic and Electronic Bandgap Materials, Ministry of Education, School of Physics and Electronic Engineering, Harbin Normal University, Harbin 150025, PR China. Electronic address:
Schottky heterostructures have significant advantages for exciting charge transfer kinetics at material interfaces. In this work, endogenous NbCT/NbO Schottky heterostructures with a large active surface area were constructed using an in-situ architectural strategy. The semiconductor NbO has a low work function, and during the construction of NbCT/NbO Schottky heterostructures, there was an interfacial electron transfer, which resulted in a built-in electric field.
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