Background: Infants under evaluation for atopic dermatitis (AD) at our clinic undergo a battery of examinations that include urinalysis and urine culture tests with antibiograms. The prevalence of cases with significant bacteriuria and leukocyturia (SBL) appeared to be unexpectedly high.
Objective: This study attempts to establish whether infants with AD should be suspected of having a higher prevalence of urinary tract infections (UTI).
Methods: A retrospective analysis of urine and urine culture tests was performed in 131 infants (84 males and 47 females) aged 1-24 months with untreated AD and in 1,327 control subjects (621 male, 706 female) aged 1-24 months.
Results: SBL was present in 27.5% of cases versus 3% of controls (p < 10(-5)). After routine treatment for AD and antibiotic treatment on the basis of a urine antibiogram, the recurrence rate of SBL, evaluated monthly over a 6-month period, was only 8.3%.
Conclusion: Infants with AD might be at a greater risk for developing UTI, and when treated for AD this risk might be reduced.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1159/000246817 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Ruxolitinib versus Roflumilast: A Meta-analysis of the Comparative Efficacy of Two Topical Therapies for Atopic Dermatitis.
J Am Acad Dermatol
March 2025
Michael G. DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada; Division of Dermatology, McMaster University, Hamilton, ON, Canada. Electronic address:
Basophil-VAMP7 is A Vital Regulator of Skin Barrier Integrity and Chronic Itch.
J Allergy Clin Immunol
March 2025
School of Biotechnology, Faculty of Science and Health, Dublin City University, Glasnevin, Dublin 9, Ireland. Electronic address:
Background: Atopic Dermatitis (AD) is a multifaceted inflammatory skin disease characterized by chronic itch and Acute Itch Flare (AIF), with basophils playing pivotal roles in both. While VAMP7 (V7) mediates immune responses, its function in basophils remains undefined.
Objective: To elucidate the role of V7 in basophil-mediated chronic itch and AIF in AD.
Use of upadacitinib in managing multiresistant atopic dermatitis.
Actas Dermosifiliogr
March 2025
Dermatology and Venereology Department, Unidade Local de Saúde de São José, Lisbon, Portugal.
How We Treat Severe Atopic Dermatitis.
Ann Allergy Asthma Immunol
March 2025
Department of Dermatology; Department of Medicine (Division of Allergy, Immunology and Rheumatology) University of Rochester Medical Center, Rochester, NY. Electronic address:
Topical Steroid Withdrawal Is a Targetable Excess of Mitochondrial NAD.
J Invest Dermatol
February 2025
Epithelial Therapeutics Unit, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA. Electronic address:
Topical steroid withdrawal (TSW) is a controversial diagnosis advocated by patients but often confused for atopic dermatitis. We conducted a multimodal pilot study of 16 patients fitting the TSW diagnostic profile, contrasting them against patients with atopic dermatitis (n = 10) and healthy controls (n = 11). Our clinical evaluations established objective diagnostic criteria that distinguish TSW from atopic dermatitis, metabolomics and transcriptomics of skin biopsies suggested that neuroinflammatory pathways are associated with complex I-mediated oxidation of NAD+, cellular and mouse models demonstrated that NAD+ metabolism was proinflammatory and glucocorticoid responsive, whereas functional assays demonstrated that the metabolic effects of glucocorticoids on the only cell type that aligns with the distribution and duration of TSW pathology could be mitigated by complex I blockade.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!