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Development and validation of a quantification method for direct oral anticoagulants from capillary blood using volumetric absorptive microsampling and online SPE-LC-MS.
J Chromatogr B Analyt Technol Biomed Life Sci
December 2024
Department of Pharmaceutical and Medical Chemistry, Clinical Pharmacy, University of Muenster, Muenster, Germany. Electronic address:
The number of prescriptions for new direct oral anticoagulants (DOACs) apixaban, edoxaban, rivaroxaban and dabigatran has increased exponentially in recent years, increasingly replacing the old gold standard, vitamin-K-antagonists. Due to their wide therapeutic range, therapeutic drug monitoring (TDM) is not required, although it has been proven that this could significantly reduce side effects. In order to develop a cost-efficient and simple method for the simultaneous detection of the DOACs and phenprocoumon, a new technology for sample preparation from capillary blood in the ambulant sector named VAMS® was integrated and an LC-MS detector with on-line solid phase extraction (SPE) applying a Turboflow HTLC Cyclone 1.
View Article and Find Full Text PDFCalibration free approaches for rapid polymorph discrimination low frequency (THz) Raman spectroscopy.
Chem Commun (Camb)
December 2024
EPSRC Future Continuous Manufacturing and Advanced Crystallisation Research Hub, University of Strathclyde, 99 George Street, Glasgow, G1 1RD, UK.
Application of multivariate curve resolution to non-invasive Raman spectra has been investigated for rapid on-line analysis of crystallisation processes and high-throughput screening. Exploring quantification of mefenamic acid solid forms (form I, form II, and dimethylformamide solvate) from the Raman spectra indicated excellent agreement with off-line X-ray analysis.
View Article and Find Full Text PDFRaman-Enabled Predictions of Protein Content and Metabolites in Biopharmaceutical Fermentations.
Eng Life Sci
December 2024
Chemical Development Novo Nordisk A/S Bagsværd Denmark.
Raman spectroscopy, a robust and non-invasive analytical method, has demonstrated significant potential for monitoring biopharmaceutical production processes. Its ability to provide detailed information about molecular vibrations makes it ideal for the detection and quantification of therapeutic proteins and critical control parameters in complex biopharmaceutical mixtures. However, its application in fermentations has been hindered by the inherent strong fluorescence background from the cells.
View Article and Find Full Text PDFHierarchically porous covalent organic framework doped monolithic column for on-line chip-based array microextraction of nonsteroidal anti-inflammatory drugs in microlitre volume of blood.
Anal Chim Acta
December 2024
Department of Chemistry, Wuhan University, Wuhan 430072, China.
Background: Traditional blood drug analysis involves large blood consumption and complicated operations and a further reduction in blood consumption is urgently needed. Chip-based monolithic column microextraction is a good strategy for the pretreatment of small-volume samples, and new monolithic materials is the critical factor. Covalent organic frameworks (COFs) are good adsorbents due to large specific surface area and rich conjugated structure.
View Article and Find Full Text PDFRaman spectroscopic quantification of polyethylene particles in water using polydimethylsiloxane-coated nickel foam as a particle-capturing platform.
Spectrochim Acta A Mol Biomol Spectrosc
February 2025
Department of Chemistry and Research Institute for Convergence of Basic Science, Hanyang University, Seoul 04763, Republic of Korea. Electronic address:
Article Synopsis
- Nickel foam (NF) was tested as a method for capturing polyethylene (PE) particles from water, showing a baseline efficiency of 69.5% when used alone.
- To improve this, NF was coated with polydimethylsiloxane (PDMS), boosting efficiency to 97.6% due to enhanced hydrophobic properties.
- The study utilized Raman spectroscopy with a wide area illumination method for accurate quantification of captured particles, demonstrating excellent capturing efficiencies for other plastics (PP, PS, PET) as well, suggesting a potential tool for detecting microplastics in water.
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