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Integrative Analysis of Androgen Receptor Interactors Aberrations and Associated Prognostic Significance in Prostate Cancer.
Urol J
October 2023
Urology Department, Affiliated Hospital of Longhua Shenzhen, Southern Medical University, Shenzhen, Guangdong 518109, China.
Purpose: Much progress has been made by directing against the adrogen receptor (AR) pathway in the treatment of prostate cancer in past decades. However, AR-interactors related metastatic castration resistant prostate cancer eventually developed. Here, we aimed to characterize the aberrations and therapeutic implication in advanced disease.
View Article and Find Full Text PDFIntegrative Analyses of Genes Associated with Subcutaneous Insulin Resistance.
Biomolecules
January 2019
Biostatistics and Bioinformatics, Chanabasava Nilaya, Bharthinagar, Dharwad 580001, Karanataka, India.
Insulin resistance is present in the majority of patients with non-insulin-dependent diabetes mellitus (NIDDM) and obesity. In this study, we aimed to investigate the key genes and potential molecular mechanism in insulin resistance. Expression profiles of the genes were extracted from the Gene Expression Omnibus (GEO) database.
View Article and Find Full Text PDFBody mass index at the presentation of premature adrenarche is associated with components of metabolic syndrome at puberty.
Eur J Pediatr
November 2018
Istanbul Faculty of Medicine, Department of Pediatrics, Division of Pediatric Endocrinology, Istanbul University, Capa, 34093, Istanbul, Turkey.
The aim of this study was to analyze the relationship between premature adrenarche (PA) and metabolic syndrome (MeS) parameters at presentation and during puberty. This study comprised 47 girls with PA. Age- and puberty-matched 22 healthy girls without PA were the control group.
View Article and Find Full Text PDFAn electrospun scaffold loaded with anti-androgen receptor compound for accelerating wound healing.
Burns Trauma
August 2016
Burns & Reconstructive Surgery Research Group, Australia ; Burns Unit, Concord Repatriation General Hospital, Concord, New South Wales 2139 Australia.
Current dermal regenerative scafolds provide wound coverage, and structural support and guidance for tissue repair, but usually lack enough bio-signals needed for speeding up skin cell growth, migration, wound closure, and skin regeneration. In this study, an androgen receptor (AR) inhibitor called ASC-J9 is used to demonstrate the concept and feasibility of fabricating drug-loaded scafolds via electrospinning. Inhibition of androgen is known to promote skin wound healing.
View Article and Find Full Text PDFElevated E-cadherin and alpha/beta-catenin expression after androgen deprivation therapy in prostate adenocarcinoma.
Pathol Res Pract
July 2004
Division of Pathology, Ospedale Vizzolo Predabissi, Melegnano (Milan), Italy.
The histological patterns of anti-androgen-treated prostate adenocarcinoma mimic high grade tumors classified according to the widely used Gleason scoring system. However, the biological characteristics of anti-androgen treated carcinoma are largely unknown. E-cadherin, alpha-catenin, and beta-catenin adhesion molecules are down-regulated in pharmacologically untreated high grade prostate carcinoma.
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