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Structural characterization and immunomodulating assessment of ultra-purified water extracted fucoidans from Saccharina latissima, Alaria esculenta and Laminaria hyperborea.
Carbohydr Polym
November 2024
Norwegian Biopolymer Laboratory (NOBIPOL), Department of Biotechnology and Food Science, NTNU Norwegian University of Science and Technology, Sem Sælands vei 6/8, 7491 Trondheim, Norway. Electronic address:
Fucoidans, a group of high molecular weight polysaccharides derived mainly from brown algae, are characterized by their high fucose content, degree of sulfation (DS), and intra- and interspecific structural variation. Fucoidans are increasingly recognized due to various reported bioactivities, potentially beneficial for human health. To unlock their potential use within biomedical applications, a better understanding of their structure-functional relationship is needed.
View Article and Find Full Text PDFComparison of Fucoidans from Regarding Age-Related Macular Degeneration Relevant Pathomechanisms in Retinal Pigment Epithelium.
Int J Mol Sci
April 2023
Department of Ophthalmology, University Medical Center, University of Kiel, Arnold-Heller-Str. 3, Haus 25, 24105 Kiel, Germany.
Article Synopsis
- - Fucoidans derived from brown algae show anti-inflammatory, antioxidative, and antiangiogenic properties, and were tested for their biological effects on age-related macular degeneration (AMD) using various retinal cell lines.
- - The study found that both fucoidans (SL-FRO and SL-NOR) reduced the secretion of proangiogenic (VEGF-A) and proinflammatory cytokines in retinal pigment epithelium (RPE) cells, indicating potential benefits against AMD.
- - While no toxic effects were observed, there were mixed results regarding gene expression and RPE barrier function, suggesting that these compounds, particularly SL-FRO, could be promising for AMD treatment but require further investigation.
Peptide Inhibitor of Complement C1 (PIC1) demonstrates antioxidant activity via single electron transport (SET) and hydrogen atom transfer (HAT).
PLoS One
June 2018
Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, Virginia, United States of America.
Reactive oxygen species (ROS) are natural byproducts of oxidative respiration that are toxic to organs and tissues. To mitigate ROS damage, organisms have evolved a variety of antioxidant systems to counteract these harmful molecules, however in certain pathological conditions these protective mechanisms can be overwhelmed. We have recently demonstrated that Peptide Inhibitor of Complement C1 (PIC1) mitigates peroxidase activity of the heme bearing proteins myeloperoxidase, hemoglobin, and myoglobin through a reversible process.
View Article and Find Full Text PDFPeptide redesign for inhibition of the complement system: Targeting age-related macular degeneration.
Mol Vis
January 2018
Department of Bioengineering, University of California, Riverside, CA.
Purpose: To redesign a complement-inhibiting peptide with the potential to become a therapeutic for dry and wet age-related macular degeneration (AMD).
Methods: We present a new potent peptide (Peptide 2) of the compstatin family. The peptide is developed by rational design, based on a mechanistic binding hypothesis, and structural and physicochemical properties derived from molecular dynamics (MD) simulation.
Variable antibody-dependent activation of complement by functionalized phospholipid nanoparticle surfaces.
J Biol Chem
January 2011
Divisions of Rheumatology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
A wide variety of nanomaterials are currently being developed for use in the detection and treatment of human diseases. However, there is no systematic way to measure and predict the action of such materials in biological contexts. Lipid-encapsulated nanoparticles (NPs) are a class of nanomaterials that includes the liposomes, the most widely used and clinically proven type of NPs.
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