The uptake of ingested aluminium (Al) from food items commonly consumed in a normal human diet was investigated by feeding five test diets to guinea pigs. Al concentrations were measured in the femur, brain, kidney and upper intestinal contents. Consumption of these diets did not lead to elevated Al levels in brain. Levels of Al in the bone were elevated in animals fed sponge cake with a permitted Al-containing additive, and the presence of citrate as orange juice enhanced bone deposition and increased kidney Al levels. Less than 1% of Al in the upper intestinal contents was found in the soluble fraction, and characterization by SEC-ICP-MS indicated that this Al was not present as Al-citrate.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/s0278-6915(09)80002-1 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Neurosteroid replacement therapy using tiagabine and zuranolone restores cerebellar neurodevelopment and reduces hyperactive behaviour following preterm birth.
J Dev Orig Health Dis
January 2025
School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, Australia.
Preterm birth exposes the neonate to hypoxic-ischaemic and excitotoxic insults that impair neurodevelopment and are magnified by the premature loss of placentally supplied, inhibitory neurosteroids. The cerebellum is a neuronally dense brain region, which undergoes critical periods of development during late gestation, when preterm births frequently occur. We propose that neurosteroid replacement therapy using tiagabine and zuranolone will protect the cerebellum against preterm-associated insults.
View Article and Find Full Text PDFSafety and Immunogenicity of the Live Attenuated Vaccine QazCOVID-Live Against Coronavirus Infection COVID-19: Pre-Clinical Study Results.
Vaccines (Basel)
December 2024
Research Institute for Biological Safety Problems, Gvardeiskiy 080409, Kazakhstan.
The research conducted in this preclinical study assesses QazCovid-live, a live attenuated COVID-19 vaccine created in Kazakhstan, by conducting preclinical evaluations of safety, immunogenicity, and allergenicity in various animal models, including mice, rats, hamsters, and guinea pigs. The vaccine, developed by attenuating SARS-CoV-2 via numerous Vero cell passages, had no significant adverse effects in acute and subacute toxicity assessments, even at elevated dosages. Allergenicity testing indicated the absence of both immediate and delayed hypersensitivity reactions.
View Article and Find Full Text PDFHerbal Extracts Mixed with Essential Oils: A Network Approach for Gastric and Intestinal Motility Disorders.
Nutrients
December 2024
Food Chemistry and Nutraceutical Laboratory, Department of Pharmacy and Biotechnology (FaBiT), Alma Mater Studiorum-University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy.
Background: Three herbal extracts ( Willd., Lorentz, and L.) were mixed with three essential oils ( Mill.
View Article and Find Full Text PDFDr. George Papanicolaou: Inventor of the Pap Smear and Father of Modern Cytology.
Cureus
December 2024
Research, Orlando College of Osteopathic Medicine, Winter Garden, USA.
The Pap smear is widely recognized in medicine as the single most successful contributor to cancer screening and preventative care. Women have Dr. George Papanicolaou (1870-1962) to thank for this groundbreaking contribution to their healthcare-a discovery that, fascinatingly, was made incidentally during his study of ovulation cycles in guinea pigs.
View Article and Find Full Text PDFMetastatic mineralization and renal intratubular crystals associated with hard drinking water in guinea pigs.
Vet Pathol
January 2025
Burdur Mehmet Akif Ersoy University, Burdur, Türkiye.
This report describes cardiovascular and renal soft tissue mineralization and renal intratubular crystals in 13 out of 16 guinea pigs that were given very hard drinking water for 9 months. These animals, aged 14 to 20 months, were experimentally naïve. No clinical symptoms were observed, but 1 guinea pig was found dead in its cage.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!