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Import of global high-risk clones is the primary driver of carbapenemase-producing in Norway.
J Med Microbiol
January 2025
Norwegian Centre for Detection of Antimicrobial Resistance, Department of Microbiology and Infection Control, University Hospital of North Norway, Troms, Norway.
Infections by carbapenemase-producing (CP-Pa) are concerning due to limited treatment options. The emergence of multidrug-resistant (MDR) high-risk clones is an essential driver in the global rise of CP-Pa. Insights into the molecular epidemiology of CP-Pa are crucial to understanding its clinical and public health impact.
View Article and Find Full Text PDFPEG-PLGA nanoparticles deposited in and .
J Pharm Anal
December 2024
Institute of Infectious Disease and Infection Control, Jena University Hospital, Jena, 07747, Germany.
In our prior research, polymer nanoparticles (NPs) containing tobramycin displayed robust antibacterial efficacy against biofilm-embedded () and (. ) cells, critical pathogens in cystic fibrosis. In the current study, we investigated the deposition of a nanoparticulate carrier composed of poly(d,l-lactic--glycolic acid) (PLGA) and poly(ethylene glycol)--PLGA (PEG-PLGA) that was either covalently bonded with cyanine-5-amine (Cy5) or noncovalently bound with freely embedded cationic rhodamine B (RhB), which served as a drug surrogate.
View Article and Find Full Text PDFPseudomonas aeruginosa Meningitis: A Case Report and Therapeutic Approach.
Cureus
December 2024
Emergency Department, Cheikh Khalifa International University Hospital, Mohammed VI International University Hospital, Casablanca, MAR.
We report the case of a 22-year-old mother with no medical history, admitted for gram-negative meningitis, identified as , 15 days after spinal anaesthesia. She was initially treated with dual antibiotic therapy, consisting of ceftazidime (2g three times a day) and amikacin. The first lumbar puncture (LP) performed 10 days approximately after the beginning of the treatment found no bacterial growth on the CSF culture.
View Article and Find Full Text PDFEvaluating racial and ethnic disparities in antibiotic treatment for pneumonia patients in a major academic health system.
Antimicrob Steward Healthc Epidemiol
December 2024
Division of Infectious Diseases, Department of Medicine, School of Medicine, Emory University, Atlanta, GA, USA.
Objective: Examine the relationship between patients' race and prescriber antibiotic choice while accounting for differences in underlying illness and infection severity.
Design: Retrospective cohort analysis.
Setting: Acute care facilities within an academic healthcare system.
Prevalence of difficult-to-treat resistance in ESKAPE pathogens in a third level hospital in Mexico.
Infect Prev Pract
March 2025
Department of Infectious Diseases, Hospital Universitario "Dr. José E. González" y Facultad de Medicina, Universidad Autónoma de Nuevo León, Mitras Centro, Monterrey, Nuevo León, CP 64460, México.
Background: Antimicrobial resistance and difficult-to-treat resistance (DTR) in ESKAPE pathogens ( and species) is a threat to human health. The aim of this study was to determine the prevalence of antimicrobial resistance and DTR rates in ESKAPE pathogens over six years in a third-level hospital from Monterrey, Mexico.
Methods: Antimicrobial susceptibility testing was determined by either disk diffusion or broth microdilution in strains from 2018 to 2023.
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