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A Novel, Site-Specific N-Linked Glycosylation Model Provides Mechanistic Insights Into the Process-Condition Dependent Distinct Fab and Fc Glycosylation of an IgG1 Monoclonal Antibody Produced by CHO VRC01 Cells.
Biotechnol Bioeng
December 2024
Department of Chemical and Biomolecular Engineering, University of Delaware, Newark, Delaware, USA.
The CHO VRC01 cell line produces an anti-HIV IgG1 monoclonal antibody containing N-linked glycans on both the Fab (variable) and Fc (constant) regions. Site-specific glycan analysis was used to measure the complex effects of cell culture process conditions on Fab and Fc glycosylation. Experimental data revealed major differences in glycan fractions across the two sites.
View Article and Find Full Text PDFAnalysis and Testing of a Flyable Micro Flapping-Wing Rotor with a Highly Efficient Elastic Mechanism.
Biomimetics (Basel)
December 2024
Centre for Aeronautics, Faculty of Engineering and Applied Sciences, Cranfield University, Bedford MK43 0AL, UK.
A Flapping-Wing Rotor (FWR) is a novel bio-inspired micro aerial vehicle configuration, featuring unique wing motions which combine active flapping and passive rotation for high lift production. Power efficiency in flight has recently emerged as a critical factor in FWR development. The current study investigates an elastic flapping mechanism to improve FWRs' power efficiency by incorporating springs into the system.
View Article and Find Full Text PDFRapid screening of esophageal squamous cell carcinoma by near-infrared spectroscopy combined with aquaphotomics.
Talanta
December 2024
NMPA Key Laboratory for Technology Research and Evaluation of Drug Products, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China; Shandong Engineering Research Center for Transdermal Drug Delivery Systems, Jinan, Shandong, 250000, China; National Glycoengineering Research Center, Shandong University, Jinan, Shandong, 250012, China. Electronic address:
Esophageal cancer (EC), the fifth most common cause of cancer-related mortality in China, poses a significant threat to public health. Among the pathological types, esophageal squamous cell carcinoma (ESCC) is predominant, comprising approximately 90 % of cases. Screening is crucial for early detection, diagnosis and treatment, thereby reducing ESCC mortality.
View Article and Find Full Text PDFUtilizing machine learning-based QSAR model to overcome standalone consensus docking limitation in beta-lactamase inhibitors screening: a proof-of-concept study.
BMC Chem
December 2024
Department of Biology, Pharmaceutical Biology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Staudtstr. 5, 91058, Erlangen, Germany.
In virtual drug screening, consensus docking is a standard in-silico approach consisting of a combined result from optimized docking experiments, a minimum of two results combination. Therefore, consensus docking is subjected to a lower success rate than the best docking method due to its mathematical nature, an unavoidable limitation. This study aims to overcome this drawback via random forest, an ensemble machine learning model.
View Article and Find Full Text PDFComparing pulsed field ablation and thermal energy catheter ablation for paroxysmal atrial fibrillation: a cost-effectiveness analysis of the ADVENT trial.
J Med Econ
December 2025
Helmsley Electrophysiology Center, Mount Sinai Fuster Heart Hospital, New York, NY, USA.
Background: Pulsed field ablation (PFA) has emerged as an effective technology in the treatment of paroxysmal atrial fibrillation (AF).
Objective: To evaluate the cost-effectiveness of PFA vs. thermal ablation from a US healthcare payer perspective using data from a randomized trial.
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