KINI is a microcomputer PC based software package which determines the one-compartment pharmacokinetic parameters for any drug using the Sawchuk-Zaske method. Through use of these programs, individualized pharmacokinetic analyses can be performed. The package allows for analysis of adult and pediatric patients, as well as offering a long and abbreviated data entry format. Additionally, KINI can generate a data file to be used with WordPerfect 5.0 or 5.1 to produce a consult for chart use.
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Computed tomographic abdominal fat volume estimation - a handy tool to predict the risk of metabolic syndrome.
Pol J Radiol
August 2023
JSS Medical College, Mysuru, Karnataka, India.
Purpose: Abdominal obesity plays a significant role in the development of metabolic syndrome, with individual metabolic risk profiles for visceral and subcutaneous adipose tissues. This study aimed to calculate and correlate the subcutaneous, visceral, and total fat compartment volume in metabolic and non-metabolic syndrome patients.
Material And Methods: This was a cross-sectional study conducted on 112 patients categorized into Group A (with metabolic syndrome) and Group B (without metabolic syndrome).
The anti-immune dengue subgenomic flaviviral RNA is present in vesicles in mosquito saliva and is associated with increased infectivity.
PLoS Pathog
March 2023
Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore.
Mosquito transmission of dengue viruses to humans starts with infection of skin resident cells at the biting site. There is great interest in identifying transmission-enhancing factors in mosquito saliva in order to counteract them. Here we report the discovery of high levels of the anti-immune subgenomic flaviviral RNA (sfRNA) in dengue virus 2-infected mosquito saliva.
View Article and Find Full Text PDFDevelopment of Gestational Age-Based Fetal Brain and Intracranial Volume Reference Norms Using Deep Learning.
AJNR Am J Neuroradiol
January 2023
From the Department of Radiology & Biomedical Imaging, University of California, San Francisco, San Francisco, California
Background And Purpose: Fetal brain MR imaging interpretations are subjective and require subspecialty expertise. We aimed to develop a deep learning algorithm for automatically measuring intracranial and brain volumes of fetal brain MRIs across gestational ages.
Materials And Methods: This retrospective study included 246 patients with singleton pregnancies at 19-38 weeks gestation.
Mutations in MAST1 Cause Mega-Corpus-Callosum Syndrome with Cerebellar Hypoplasia and Cortical Malformations.
Neuron
December 2018
Research Institute of Molecular Pathology, Campus Vienna Biocenter 1, Vienna Biocenter (VBC), Vienna 1030, Austria. Electronic address:
Corpus callosum malformations are associated with a broad range of neurodevelopmental diseases. We report that de novo mutations in MAST1 cause mega-corpus-callosum syndrome with cerebellar hypoplasia and cortical malformations (MCC-CH-CM) in the absence of megalencephaly. We show that MAST1 is a microtubule-associated protein that is predominantly expressed in post-mitotic neurons and is present in both dendritic and axonal compartments.
View Article and Find Full Text PDFSatisfactory outcomes following combined unicompartmental knee replacement and anterior cruciate ligament reconstruction.
Knee Surg Sports Traumatol Arthrosc
September 2018
Department of Orthopaedic Surgery, Erasmus MC, University Medical Centre Rotterdam, s' Gravendijkwal 230, 3000 CA, Rotterdam, The Netherlands.
Purpose: There exist limited options for treatment of patients with combined medial compartment arthritis and anterior cruciate ligament (ACL) deficiency. Ideal treatment is one that offers lasting relief of symptoms not compromising any future surgery. Unicompartmental knee replacement has shown consistently good results in the relatively young and active population, but there is a high reported incidence of failure up to 20%, if performed in ACL-deficient knees.
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