The aim of the present work was to test the effect of aging on the capacity to perform and validate simple arithmetic calculations. Two experimental groups, eight young and eight old subjects, performed a set of three tasks (A,B,C), requiring different amounts of attentional resources. In test A, the subjects knew in advance the type of operation to be validated; in test B the subjects had to validate items of four randomly mixed operation types; in test C the subjects could use an informative cue which signalled in advance the kind of operation to be performed. The cue was true in 70% of items (valid trials) and false in 30% (invalid trials). The results confirmed a slowing down of cognitive processes in old people that partially depended on task complexity. Differently from young, old subjects could not use the informative cue to orient attention toward specific arithmetic facts: actually in test C the difference between invalid vs. valid trials does not reach statistical significance.
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Drugs Aging
January 2025
Program for the Care and Study of the Aging Heart, Department of Medicine, Weill Cornell Medicine, 420 East 70th St, New York, NY, LH-36510063, USA.
There are several pharmacologic agents that have been touted as guideline-directed medical therapy for heart failure with preserved ejection fraction (HFpEF). However, it is important to recognize that older adults with HFpEF also contend with an increased risk for adverse effects from medications due to age-related changes in pharmacokinetics and pharmacodynamics of medications, as well as the concurrence of geriatric conditions such as polypharmacy and frailty. With this review, we discuss the underlying evidence for the benefits of various treatments in HFpEF and incorporate key considerations for older adults, a subpopulation that may be at higher risk for adverse drug events.
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Department of Biomedical Engineering, College of Chemistry and Life Sciences, Beijing University of Technology, Beijing, 100124, China.
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Department of Kinesiology and Public Health, California Polytechnic State University San Luis Obispo, San Luis Obispo, CA, USA.
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Institute for Behavioral and Community Health, San Diego State University, San Diego, CA, USA.
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