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Antibiotic multidrug resistance in the cystic fibrosis airway microbiome is associated with decreased diversity.
Heliyon
September 2018
Computational Biology Institute, Milken Institute School of Public Health, George Washington University, Washington, DC, USA.
Background: Cystic fibrosis (CF) is associated with significant morbidity and early mortality due to recurrent acute and chronic lung infections. The chronic use of multiple antibiotics increases the possibility of multidrug resistance (MDR). Antibiotic susceptibility determined by culture-based techniques may not fully represent the resistance profile.
View Article and Find Full Text PDFSevere keratitis with deep corneal involvement.
Am J Ophthalmol Case Rep
September 2018
Wilmer Eye Institute, Johns Hopkins University School of Medicine, 600 N Wolfe St, Wilmer, Baltimore, MD, 21287, USA.
Purpose: To describe a case of keratitis with deep involvement of the corneal stroma and discuss its management.
Observations: A 73 year-old monocular male with infectious keratitis of the right eye was referred to the Wilmer Eye Institute after a month of empiric treatment with besifloxacin. On presentation, slit lamp examination of the right eye demonstrated a diffusely edematous cornea with three areas of corneal infiltrates and an overlying epithelial defect and a 1.
Polymicrobial Infection of the Cornea Due to Contact Lens Wear.
Turk J Ophthalmol
April 2016
Çukurova University Faculty of Medicine, Department of Ophthalmology, Adana, Turkey.
A 38-year-old male presented with pain and redness in his left eye. He had a history of wearing contact lenses. His ophthalmic examination revealed a large corneal ulcer with surrounding infiltrate.
View Article and Find Full Text PDFAlcaligenes xylosoxidans endocarditis of a prosthetic valve and pacemaker in a 62-year-old woman.
Tex Heart Inst J
August 2013
Department of Internal Medicine, Community Regional Medical Center, Fresno, California 93701, USA.
The bacterium Alcaligenes xylosoxidans is known to cause several nosocomial infections; however, it rarely causes endocarditis, which has a very high mortality rate. Early isolation of the infection source and prompt identification of the patient's antibiotic sensitivities are paramount if the infection is to be treated adequately. We present what is apparently only the second documented case of the successful eradication of bioprosthetic valve endocarditis that was caused by pacemaker lead infection with Alcaligenes xylosoxidans.
View Article and Find Full Text PDFChronic laminitis is associated with potential bacterial pathogens in the laminae.
Vet Microbiol
August 2012
Equine Science Center, Rutgers University, New Brunswick, NJ 08901, USA.
A common sequella of chronic laminitis in horses is repeated abscesses with variable lameness and drainage. It is unclear whether the exudate represents the debridement phase of a non-septic inflammatory process involving clearance of laminar tissue damaged during the acute episode of laminitis, or a response to a microbial infection developed by ascent of microbes from the environment to the tissue via the white line. The objective of this study was to evaluate the possibility that an undiagnosed microbial infection in laminar tissue is present in laminar tissue collected from chronically laminitic horses without an active hoof abscess.
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