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[Influence of prodigiozan-dependent comuton on the resistance of liver mitochondria against damage by protonofor].
Vestn Ross Akad Med Nauk
September 2014
An effector of tissue stress of hepatocytes, prodigiozan-dependent comuton (PDC), provokes deenergiezation of liver mitochondria, preloaded by Ca2+ ions. In this case a decrease of membrane potential (MP) and Ca2+ efflux by cyclosporine A sensitive mechanism of megapore is observed. If megapore is blocked by cyclosporin A, protonofor FCCP provoked decrease of MP and Ca2+ efflux by cyclosporin A-insensitive mechanism.
View Article and Find Full Text PDF[Intraorganic and intratissue mechanisms of protective action of activated Kupffer cells on hepatocytes].
Vestn Ross Akad Med Nauk
August 2013
Endotoxine activated Kupfer cells release into the intercellular space several mediators which act directly on hepatocytes as well as via stellet cells. In both cases Kupfer cells downregulate hepatocytes as a part of paracrine system. However, downregulated part of liver parenchyma might be extended by several mechanisms.
View Article and Find Full Text PDFActivity of neutrophil β-glucuronidase in diabetic and nondiabetic patients with chronic generalized periodontitis and healthy subjects.
Medicina (Kaunas)
January 2012
Department of Dental and Maxillofacial Orthopedics, Medical Academy, Lithuanian University of Health Sciences, Sukilėlių, Kaunas.
OBJECTIVE. The aim of the study was to establish the dynamics of β-glucuronidase activity in subjects suffering from type 1 diabetes and chronic untreated generalized periodontitis, subjects suffering from chronic untreated generalized periodontitis only, and control subjects not suffering from generic diseases with healthy periodontal tissue. MATERIAL AND METHODS.
View Article and Find Full Text PDFStudy of influence of prodigiozan-dependent comuton on slow efflux of calcium ions from the matrix of mitochondria of various tissue and species origins.
Dokl Biochem Biophys
July 2011
Association for World Laboratory, Biomedical Center, Moscow, Russia.
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