The morphological study showed that the single injection of HMP (Hydra Morphogen Peptide) facilitated the development of the myocardium hypertrophy. This effect is expressed in the subendocardial layer most of all, where the normalization of the relative volume and diameter of the cardiomyocytes and the decrease of the connective tissue oedema are noted. These parameters are normalized in the intramural and subepicardial layers in less degree. The decrease of the connective tissue oedema is noted in the intramural layer. The normal correlation recovery between the relative volumes of the cardiomyocytes and the connective tissue is shown in the subepicardial layer, the diameters of the myocytes are essentially increased. The influence of HMP is manifested not only on the muscular and connective tissue components of the myocardium, but touches on also the system of the myocardial wall vessels, causing the redistribution of the intramural blood circulation.
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Calcif Tissue Int
January 2025
Division of Bone Diseases, Department of Medicine, Geneva University Hospitals, Geneva, Switzerland.
Tumor-induced osteomalacia (TIO) is a rare acquired paraneoplastic syndrome caused by a mesenchymal tumor secreting a phosphaturic hormone called FGF23. Patients present with bone pain, fragility fractures and muscle weakness. Biochemical results show hypophosphatemia, raised serum alkaline phosphatase and reduced calcitriol.
View Article and Find Full Text PDFInt J Implant Dent
January 2025
Department of Advanced Prosthodontics, Hiroshima University Graduate School of Biomedical and Health Sciences, 1-2-3 Kasumi, Minami-ku, Hiroshima City, 734-8553, Hiroshima, Japan.
Purpose: The study aimed to examine the usefulness of a novel density measurement drill for evaluating cancellous bone density by examining the correlation between computed tomography (CT)-based Misch bone density classification and drilling torque value.
Methods: Bovine ribs were used as the drilling sites for implant placement. Multidetector CT (MDCT) was performed after contrast materials were attached to the drilling sites.
J Esthet Restor Dent
January 2025
Department of Periodontology, Operative and Preventive Dentistry, University of Bonn, Bonn, Germany.
Objectives: To clinically evaluate the outcomes following surgical coverage of single peri-implant mucosal recessions in the aesthetic maxillary area by means of the modified coronally advanced tunnel (MCAT) and subepithelial connective tissue graft (SCTG).
Materials And Methods: Eleven systemically healthy non-smoking patients (8 females) each presenting a single peri-implant mucosal recession in the anterior maxillary region were consecutively treated with MCAT in conjunction with SCTG. In all cases, the facial recession was associated with an impaired aesthetic appearance.
J Clin Periodontol
January 2025
Clinic of Reconstructive Dentistry, University of Zurich, Zurich, Switzerland.
Aim: To compare the histological structure of biopsies from the anterior and posterior regions of the human palate in order to gain insights into potential differences of soft tissue harvesting sites.
Methods: This comparative study involved 20 participants, from each of whom four samples from the palatal mucosa were collected. The biopsies were histologically processed and subsequently analysed.
J Cachexia Sarcopenia Muscle
February 2025
Department of Biomedicine, Aarhus University, Aarhus, Denmark.
Background: Anti-Activin Receptor Type IIA and Type IIB antibody (αActRIIA/IIB ab) is a recently developed drug class that targets the activin receptor signalling pathway. Inhibition of receptor ligands (activins, myostatin, growth differentiation factor 11, etc.) can lead to skeletal muscle hypertrophy, bone formation, and increased haematopoiesis.
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