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http://dx.doi.org/10.1056/NEJM197506192922514 | DOI Listing |
Pediatr Blood Cancer
August 2024
Division of Pediatric Hematology and Oncology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Haematologica
October 2024
Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital Medical Centre, Cincinnati, OH USA; Department of Paediatrics, University of Cincinnati College of Medicine, Cincinnati.
J Hematol Oncol
April 2024
Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany.
Constitutional heterozygous pathogenic variants in genes coding for some components of the Fanconi anemia-BRCA signaling pathway, which repairs DNA interstrand crosslinks, represent risk factors for common cancers, including breast, ovarian, pancreatic and prostate cancer. A high cancer risk is also a main clinical feature in patients with Fanconi anemia (FA), a rare condition characterized by bone marrow failure, endocrine and physical abnormalities. The mainly recessive condition is caused by germline pathogenic variants in one of 21 FA-BRCA pathway genes.
View Article and Find Full Text PDFJ Hematop
June 2024
Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Pediatr Blood Cancer
February 2024
Department of Radiation Oncology, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
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