Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1177/030098589403100311 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Resveratrol Butyrate Esters Reduce Hypertension in a Juvenile Rat Model of Chronic Kidney Disease Exacerbated by Microplastics.
Nutrients
November 2024
Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan.
Article Synopsis
- - Resveratrol butyrate esters (RBEs) were developed to improve the bioactivity of resveratrol, a compound known for its potential benefits in managing hypertension and promoting gut health.
- - A study with juvenile rats showed that exposure to microplastics worsened hypertension caused by chronic kidney disease (CKD), but treatment with RBE significantly lowered blood pressure and improved nitric oxide levels.
- - RBE treatment also positively influenced the renin-angiotensin system, gut microbiome composition, and increased the levels of butyric acid, indicating a multifaceted mechanism for its antihypertensive effects.
Potentially toxic elements in wild Agassiz's desert tortoises: tissue concentrations and association with disease.
Front Vet Sci
November 2024
Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL, United States.
Article Synopsis
- Desert tortoise populations are declining due to diseases, predation, and habitat changes, raising questions about the role of minerals and heavy metals in their health.
- This study analyzed trace minerals and heavy metals in the tissues of sick and dying tortoises to explore their impact on health.
- Results showed that certain toxic metals were present in all tortoises, with juveniles showing higher levels of lead, tin, and zinc, indicating possible environmental health risks for these animals.
Eosinophilic inflammation that begins in the juvenile stage causes hydronephrosis and urothelial cancer in mutant mice.
Sci Rep
December 2024
Laboratory of Pathology, Faculty of Pharmaceutical Sciences, Setsunan University, 573-0101, Hirakata, Japan.
Obstructive hydronephrosis is caused by various factors such as chronic inflammation and tumors. Eosinophils and chitinase-like proteins (CLPs) are involved in the pathogenesis of hydronephrosis in mice; however, the specific mechanisms remain unknown. In this study, we morphologically analyzed a novel mouse model of obstructive hydronephrosis from onset to progression to clarify the effects of eosinophils and CLP on the development of hydronephrosis and tumorigenesis.
View Article and Find Full Text PDFEnzyme-activatable kidney-targeted dendrimer-drug conjugate for efficient childhood nephrotic syndrome therapy.
Theranostics
December 2024
Department of Pediatrics, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Zhejiang Chinese Medical University, Hangzhou 310006, China.
Childhood nephrotic syndrome (NS) is a serious disease affecting the health and quality of life of children, which is characterized by a series of pathophysiological changes due to the increased permeability of the glomerular membrane to plasma proteins. Low renal drug distribution and inefficient cellular uptake, resulting from cellular dysfunctions of filtration and internalization, are the main barriers to drug treatment in childhood NS, leading to deterioration in nephropathy. However, efficient therapeutic methods against childhood NS are still lacking in clinic.
View Article and Find Full Text PDFThe Co-Infection of ISKNV-II and RGNNV Resulting in Mass Mortality of Juvenile Asian Seabass (Lates calcarifer), Zhuhai, Southern China.
J Fish Dis
December 2024
State Key Laboratory of Biocontrol (SKLBC, Guangzhou)/Southern Marine Science and Engineering Guangdong Laboratory (SML, Zhuhai), School of Life Sciences of Sun Yat-Sen University, Guangzhou, China.
Infectious spleen and kidney necrosis virus (ISKNV) and nervous necrosis virus (NNV) are two common and important causative agents in marine-cultured fish. However, high viral loads of both ISKNV and NNV in the same clinical case is unusual. In this study, a mass mortality event of Asian seabass Lates calcarifer juveniles occurred in Zhuhai, the main Asian seabass cultured area in mainland China.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!