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The global impact of the COVID-19 pandemic on delays and disruptions in cancer care services: a systematic review and meta-analysis.
Nat Cancer
January 2025
Cancer Surveillance Branch, International Agency for Research on Cancer, Lyon, France.
The coronavirus disease 2019 pandemic substantially impacted the delivery of cancer services and programs. Here we reviewed and synthesized the global scale and impact of pandemic-related delays and disruptions on cancer services, including diagnosis, diagnostic procedures, screening, treatment and supportive and palliative care. Based on data from 245 articles in 46 countries, we observed declines in the number of cancer screening participation (39.
View Article and Find Full Text PDFUsing machine learning to identify risk factors for short-term complications following thumb carpometacarpal arthroplasty.
J Hand Microsurg
December 2024
Department of Orthopaedic Surgery, University of Chicago Pritzker School of Medicine, Chicago, IL, USA.
Background: Thumb carpometacarpal (CMC) joint osteoarthritis is among the most common degenerative hand diseases. Thumb CMC arthroplasty, or trapeziectomy with or without tendon augmentation, is the most frequently performed surgical treatment and has a strong safety profile. Though adverse outcomes are infrequent, the ability to predict risk for complications has substantial clinical benefits.
View Article and Find Full Text PDFStudy protocol for the PICASSO trial: A randomized placebo-controlled trial to investigate the efficacy and safety of intraarticular steroid injections and an occupational therapy intervention in painful inflammatory carpometacarpal-1 osteoarthritis.
Osteoarthr Cartil Open
March 2025
Center for Treatment of Rheumatic and Musculoskeletal Diseases (REMEDY), Diakonhjemmet Hospital, Oslo, Norway.
Objective: Our primary objectives are to assess whether intraarticular corticosteroid injections are superior to saline injections with regards to thumb base pain after 4 weeks, and to compare the efficacy of steroid injections, saline injections, and an occupational therapy intervention on thumb base pain after 12 weeks in people with painful inflammatory osteoarthritis (OA) of the first carpometacarpal (CMC-1) joint.
Design: In this three-armed, double-blind, randomized multicenter trial, 354 participants with painful inflammatory CMC-1 OA from six Norwegian hospitals are recruited. Participants are randomized 1:1:1 to intraarticular steroid or saline injections in the CMC-1 joint or a multimodal occupational therapy intervention.
Stabilization of the Thumb Carpometacarpal Joint Utilizing a Minimally Invasive Approach: A Novel Technique.
Tech Hand Up Extrem Surg
December 2024
Division of Hand & Upper Extremity Surgery, Department of Orthopaedic Surgery, Harvard Medical School.
Treatment of symptomatic thumb carpometacarpal (CMC) joint synovitis can be challenging. Surgical options in these patients are often limited due to the patient's youth and lack of arthrosis. One of the most commonly used techniques involves the use of the flexor carpi radialis to reconstruct the ligamentous complex of the thumb CMC joint.
View Article and Find Full Text PDFHigh-concentrated platelet-rich plasma (PRP) versus placebo in osteoarthritis in the thumb base: study protocol for an assessor-blinded randomized controlled trial.
Trials
November 2024
Department of Clinical Science and Education, Karolinska Institutet, Stockholm, Sweden.
Article Synopsis
- Osteoarthritis in the thumb base is common, especially in middle-aged and older women, leading to significant disability, prompting the need for effective treatments beyond traditional methods like steroid injections.
- A controlled trial is set to compare the effectiveness of high-concentration platelet-rich plasma (PRP) injections against saline (placebo) for pain relief and functional improvement in patients with thumb base osteoarthritis.
- The study will evaluate pain and functional outcomes over a year, aiming to determine if PRP provides significant benefits compared to the placebo, filling a gap in current evidence about its efficacy.
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