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Are oligodendrocytes bystanders or drivers of Parkinson's disease pathology?
PLoS Biol
January 2025
Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.
The major pathological feature of Parkinson 's disease (PD), the second most common neurodegenerative disease and most common movement disorder, is the predominant degeneration of dopaminergic neurons in the substantia nigra, a part of the midbrain. Despite decades of research, the molecular mechanisms of the origin of the disease remain unknown. While the disease was initially viewed as a purely neuronal disorder, results from single-cell transcriptomics have suggested that oligodendrocytes may play an important role in the early stages of Parkinson's.
View Article and Find Full Text PDF- still a mysterious parasite.
Helminthologia
September 2024
School of Chemical and Biological Sciences, Autonomous University of Sinaloa, Culiacan, Sinaloa, Mexico.
The recent publication entitled "Possible zoonotic implications of the discovery of the advanced third stage larva of (Spirurida: Gnathostomatidae) in a Mexican fish species" by Mosqueda-Cabrera ., appeared in Helminthologia, 2023; 60(1): 112-116. was extremely interesting and informative showing potential zoonotic natue of .
View Article and Find Full Text PDFOsteocyte Dendrites: How Do They Grow, Mature, and Degenerate in Mineralized Bone?
Cytoskeleton (Hoboken)
December 2024
Department of Biomedical Engineering, University of Delaware, Newark, Delaware, USA.
Osteocytes, the most abundant bone cells, form an extensive cellular network via interconnecting dendrites. Like neurons in the brain, the long-lived osteocytes perceive mechanical and biological inputs and signal to other effector cells, leading to the homeostasis and turnover of bone tissues. Despite the appreciation of osteocytes' vital roles in bone biology, the initiation, growth, maintenance, and eventual degradation of osteocyte dendrites are poorly understood due to their full encasement by mineralized matrix.
View Article and Find Full Text PDFHow biophysics shapes the origins of life: a 21st IUPAB/62nd BSJ joint congress symposium overview.
Biophys Rev
October 2024
Department of Electrical Engineering and Bioscience, Faculty of Science and Engineering, Waseda University, 2-2 Wakamatsu, Shinjuku, Tokyo 162-8480 Japan.
The origins of life remains an unsolved mystery for all of humankind which requires a uniquely interdisciplinary approach incorporating many different subfields from astronomy, to geology, to chemistry, to biology, and beyond. One of these subfields which contributes greatly to understanding of various aspects of the origins of life is biophysics. As part of the 21st IUPAB/62nd BSJ Joint Congress in Kyoto, Japan, a symposium on the Origin of Life was held on June 28, 2024, featuring invited and contributed presentations on various aspects of origins of life research from Japan and around the world.
View Article and Find Full Text PDFSynthesis and Stability of Biomolecules in C-H-O-N Fluids under Earth's Upper Mantle Conditions.
J Am Chem Soc
November 2024
Department of Physics, Hong Kong University of Science and Technology, Hong Kong 999077, China.
How life started on Earth is an unsolved mystery. There are various hypotheses for the location ranging from outer space to the seafloor, subseafloor, or potentially deeper. Here, we applied extensive ab initio molecular dynamics simulations to study chemical reactions between NH, HO, H, and CO at pressures () and temperatures () approximating the conditions of Earth's upper mantle (i.
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