AI Article Synopsis
- The study examines the function of neurotrophin-3 in the development of quail sensory ganglia, using a monoclonal antibody to block its activity.
- Neutralizing neurotrophin-3 during gangliogenesis leads to a significant loss of approximately 30% of neurons in both the placode-derived ganglion nodosum and the neural crest-derived dorsal root ganglion.
- The findings highlight that neurotrophin-3 is crucial for early neuronal survival during the formation of these ganglia, with comparisons made to effects seen when using an antibody against nerve growth factor.
Article Abstract
The role played by neurotrophin-3 during the development of quail sensory ganglia was investigated using a monoclonal antibody that specifically blocks the biological activity of this neurotrophin. Neutralisation of neurotrophin-3 was initiated during completion of gangliogenesis. Neuronal cell counts indicate that about 30% of the neurons normally present in either the placode-derived ganglion nodosum or in a leg-innervating, neural crest-derived dorsal root ganglion are eliminated by the antibody treatment. In both ganglia, this reduction is seen early in development, and the results obtained with the ganglion nodosum indicate that neurotrophin-3 plays an essential role already during gangliogenesis. Neuronal numbers are also compared with those obtained after treatment with a monoclonal antibody to nerve growth factor, used either alone or in combination with the neurotrophin-3 antibody.
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| http://dx.doi.org/10.1242/dev.120.6.1613 | DOI Listing |
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