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A 'good death' needs good cooperation with health care professionals - a qualitative focus group study with seniors, physicians and nurses in Germany.
BMC Palliat Care
December 2024
Department of General Practice, University Medical Center Göttingen, Humboldtallee 38, Göttingen, 37073, Germany.
Background: Studies investigating notions of a 'good death' tend to focus on specific medical conditions and specific groups of people. Therefore, their results are often poorly comparable, making it difficult to anticipate potential points of conflict in practice. Consequently, the study explores how to achieve a good death from the perspective and experience of physicians, nursing staff, and seniors.
View Article and Find Full Text PDFOpinion of Polish doctors on the use of futile therapy.
Eur J Public Health
December 2024
Department of Anesthesiology and Intensive Therapy, Silesian Centre for Heart Diseases in Zabrze, Medical University of Silesia, Zabrze, Poland.
The discontinuation of futile therapy is increasingly discussed in Polish clinical practice. Given the need to ensure patient well-being, it is essential to consider whether all clinical options resulting from medical progress should be used for every patient and on what grounds decisions to limit therapy should be based. The aim of our study was to determine the opinions of Polish medical doctors on this topic.
View Article and Find Full Text PDFBayesian Safety and Futility Monitoring in Phase II Trials Using One Utility-Based Rule.
Stat Med
December 2024
Department of Biostatistics, UT M.D. Anderson Cancer Center, Houston, Texas.
For phase II clinical trials that determine the acceptability of an experimental treatment based on ordinal toxicity and ordinal response, most monitoring methods require each ordinal outcome to be dichotomized using a selected cut-point. This allows two early stopping rules to be constructed that compare marginal probabilities of toxicity and response to respective upper and lower limits. Important problems with this approach are loss of information due to dichotomization, dependence of treatment acceptability decisions on precisely how each ordinal variable is dichotomized, and ignoring association between the two outcomes.
View Article and Find Full Text PDFEnhanced thermal stability enables human mismatch-specific thymine-DNA glycosylase to catalyse futile DNA repair.
PLoS One
October 2024
Group «Mechanisms of DNA Repair and Carcinogenesis», CNRS UMR9019, Université Paris-Saclay, Gustave Roussy Cancer Campus, Villejuif Cedex, France.
Human thymine-DNA glycosylase (TDG) excises T mispaired with G in a CpG context to initiate the base excision repair (BER) pathway. TDG is also involved in epigenetic regulation of gene expression by participating in active DNA demethylation. Here we demonstrate that under extended incubation time the full-length TDG (TDGFL), but neither its isolated catalytic domain (TDGcat) nor methyl-CpG binding domain-containing protein 4 (MBD4) DNA glycosylase, exhibits significant excision activity towards T and C in regular non-damaged DNA duplex in TpG/CpA and CpG/CpG contexts.
View Article and Find Full Text PDFGuidance of Erupting First Permanent Molar in Complex Clinical Scenarios: A Case Series.
Int J Clin Pediatr Dent
March 2024
Department of Pediatric and Preventive Dentistry, Dr D Y Patil Dental College & Hospital, Dr D Y Patil Vidyapeeth (Deemed to be University), Pune, Maharashtra, India.
Aim: The aim of this current case series is to propose various design modifications of the conventional distal shoe space maintainers in relation to complex clinical scenarios.
Background: Primary dentition plays a significant role in preserving space for underlying unerupted permanent teeth; early childhood caries (ECC) is a serious public health problem in both developing and developed countries, and it is often left untreated. Its consequences can have an immediate and long-term impact on the child's quality of life and overall health.
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