The immunity parameters were studied in 42 pregnant women, HBsAg carriers, both clinically healthy and suffering from chronic liver diseases. Sixty pregnant women without liver diseases or HBs-antigenemia made up the reference group. A marked T-cellular immunodeficiency was revealed in pregnant women with persistent HBs-antigenemia and chronic persistent hepatitis, in contrast to the clinically healthy women whose cellular immunity parameters were the same as in healthy pregnant women. Besides cellular immunodeficiency, the pregnant women with HBs-positive chronic persistent hepatitis presented with a marked imbalance of the humoral immunity parameters and hypersensitization to liver lipoprotein, this indicating manifest shifts in the immunity system. Spontaneous abortions occurred much more often in women with chronic persistent or active hepatitides than in the controls. The authors claim that screening of pregnant women for HBsAg is advisable for deciding on the policy of pregnancy management.
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