A method for early diagnosis of cholelithiasis on a basis of the hemagglutination inhibition reaction has been suggested. A method is realized in interaction of a specific agglutinogen obtained from lithogenic bile with the human blood serum and erythrocytes of white mongrel rats. It was established that agglutinogen is a protein with a low molecular mass of 55,000-75,000. A specificity of the method is 74-100%. The method is simple in technical performance, needs no special equipment and training of personnel. High productivity (150-200 analyses can be performed by one investigator per one shift) as compared to ultrasound investigation makes it capable to compete in mass screenings.

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