Allozyme variability in 37 strains of soil bacilli related to Bacillus subtilis was studied. A study of electrophoretic mobility of corresponding enzymes showed that, with one exception the strains did not differ essentially from the standard strain Bacillus subtilis 168 Marburg, in accordance with the results on electrophoretic mobility of corresponding enzymes. However, considerable genetic diversity was revealed at the intraspecific level in the population of bacilli under study. Of the 8 isoenzyme loci, 7 were polymorphic, and the average number of alleles per locus was 3.14. The extent of genetic diversity and the Nei's genetic distance were, on average 0.28 and 0.46, respectively. Significant correlation (r = 0.836) between the value of genetic distance and the level of the DNA-DNA hybridization of the strains was demonstrated.
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Food Environ Virol
January 2025
Division of Agriculture, Department of Food Science, University of Arkansas, 1371 West Altheimer Dr, Fayetteville, AR, 72704, USA.
The transmission and infection of enteric viruses can be influenced by co-existing bacteria within the environment and host. However, the viral binding ligands on bacteria and the underlying interaction mechanisms remain unclear. This study characterized the association of norovirus surrogate Tulane virus (TuV) and murine norovirus (MNV) as well as the human enteric virus Aichi virus (AiV) with six bacteria strains (Pantoea agglomerans, Pantoea ananatis, Bacillus cereus, Enterobacter cloacae, Exiguobacterium sibiricum, Pseudomonas spp.
View Article and Find Full Text PDFAm J Cardiol
January 2025
Division of Cardiology, Department of medicine, University of Verona, Verona, Italy.
Tricuspid regurgitation (TR) is related to survival and right atrial (RA) size and function may play a role. Our objective is to assess the impact of RA function measured by strain (RAS) on outcome and end organ congestion. We enrolled 134 patients (mean age 73 ± 13 years, 62% women) with any TR grade or etiology and a complete echocardiogram, clinical follow up and renal function assessment.
View Article and Find Full Text PDFBackground: Animal models provide a valuable basis for identification of conserved pathological substrates and processes underlying age-related diseases as well as neurobiological features supporting cognitive resilience in the aging brain. Behavioral measures are a fundamental component in the assessment of cognitive processes but are rarely standardized across laboratories. Currently, there is a scarcity of centralized and standardized data infrastructure for behavioral experiment data collected across laboratories which presents a barrier for data sharing, hypothesis generation, and collaboration.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
The University of Texas Health Science Center at Houston, Houston, TX, USA.
Background: Alzheimer's disease (AD) is an heterogenous disorder characterized by the accumulation of amyloid-beta (Aβ) and tau. One possible explanation for the clinical and pathological variation in AD lies in the presence of distinct conformational strains of Aβ. Numerous studies provide compelling evidence for the existence of such strains as well as their ability to template their conformations in a prion-like manner.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
University of Pennsylvania, Philadelphia, PA, USA.
Background: Granulovacuolar degeneration (GVD) is a common feature in Alzheimer's disease (AD) and other tauopathies such as corticobasal degeneration (CBD), progressive supranuclear palsy (PSP), and Pick's disease (PiD). Despite its prevalence, much remains unknown about the role of GVD in the pathobiology of these diseases. Morphologically, GVD is characterized by intraneuronal membrane-bound vacuoles, also known as GVD bodies (GVBs).
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