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Smooth Muscle and Adenoma-Like Renal Tumor (SMART)- A Rare Biphasic Renal Tumor with a Review.
Int J Surg Pathol
December 2024
Department of Pathology and Lab Medicine, All India Institute of Medical Sciences (AIIMS), Bhubaneswar, India.
Smooth muscle and adenoma-like renal tumor (SMART) is a biphasic tumor composed of cytologically bland stromal and epithelial components. It has many histopathological mimickers. A 57-year-old man presented with a left renal mass.
View Article and Find Full Text PDFFumarate hydratase-deficient renal cell carcinoma: a single institution-based study of 29 patients by clinicopathological, immunohistochemical and genetic approaches.
Pathology
February 2025
Department of Pathology, Seoul National University College of Medicine, Seoul, Republic of Korea; Kidney Research Institute, Medical Research Center, Seoul National University College of Medicine, Seoul, Republic of Korea. Electronic address:
Fumarate hydratase (FH)-deficient renal cell carcinoma (RCC) is a renal neoplasm associated with FH loss, aggressive behaviour, and poor survival. We present a histopathological and immunohistochemical overview of FH-deficient RCC to infer significant features for its differential diagnosis. In this study, FH-deficient RCC tissue samples from patients who underwent surgical resection or biopsy at a single institution between July 1995 and August 2022 were reviewed by conventional haematoxylin and eosin staining, immunohistochemistry, and whole genome analyses.
View Article and Find Full Text PDFFerroptosis of select skin epithelial cells initiates and maintains chronic systemic immune-mediated psoriatic disease.
J Clin Invest
November 2024
Department of Dermatology.
Dysregulations of epithelial-immune interactions frequently culminate in chronic inflammatory diseases of the skin, lungs, kidneys, and gastrointestinal tract. Yet, the intraepithelial processes that initiate and perpetuate inflammation in these organs are poorly understood. Here, by utilizing redox lipidomics we identified ferroptosis-associated peroxidation of polyunsaturated phosphatidylethanolamines in the epithelia of patients with asthma, cystic fibrosis, psoriasis, and renal failure.
View Article and Find Full Text PDFMetastatic renal cell carcinoma with fibromyomatous stroma associated with tuberous sclerosis or MTOR, TSC1/TSC2-Mutations: A Series of 4 cases and a review of the literature.
Hum Pathol
November 2024
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, 55905, USA. Electronic address:
Renal cell carcinoma with fibromyomatous stroma (RCCfms) are characterized by a constellation of morphologic findings that include elongated tubules lined by cells with clear to pale eosinophilic cytoplasm and intersecting bands of smooth muscle stroma. Consistent immunohistochemistry findings in RCCfms include diffuse positivity for carbonic anhydrase 9 and variable expression of keratin 7. Molecular profiling of such tumors show either pathogenic alterations of the ELOC (TCEB1) gene, or alterations of MTOR, TSC1, and TSC2.
View Article and Find Full Text PDFKeratin 20 positive SDH-deficient renal cell carcinoma: a case report and literature review.
Diagn Pathol
October 2024
Department of Pathology, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou University, Yangzhou, Jiangsu, 225000, China.
Article Synopsis
- * It involved a detailed analysis of a 57-year-old female patient with specific tumor characteristics, including clear boundaries, a glandular arrangement, and SDHB-negative results from immunohistochemistry staining.
- * The findings indicate that SDH-deficient renal cell carcinoma, linked to SDH gene mutations, usually has a good prognosis, but cases lacking differentiation necessitate long-term monitoring.
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