The effect of temporary skin resurfacing on processes developing in the skin surrounding post-thermal-burn wounds is morphologically studied in experiment. The burned wound region and perilesional area are immediately covered by a fresh allograft, xenograft, Ampoxen, Pharmexplant and Deflamol ointment. Tissue specimens for histological evaluation are taken within 3, 7 and 14 days. The processes developing within the wound and in the perilesional area under a fresh allograft and Deflamol ointment appear to be the most beneficial. Here the inflammatory response is substantially milder, and regardless of the latter, the regeneration and even differentiation of cells in the course of healing are more clearcut, as compared to the other resurfacing methods used in the experiment.
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Burns
January 2025
Jiangsu Tech-Bio-Med Medical Equipment Co.,Ltd., Changzhou, Jiangsu 213000, China.
Background: Wound closure is the core issue in treating patients with extensive burns. Allogeneic grafts can serve as a suitable temporary substitute in third-degree burns, and the Meek technique has provided encouraging outcomes in recent decades. However, whether allografts and the Meek technique could be used simultaneously so as to leverage the strengths of both has not been extensively examined.
View Article and Find Full Text PDFJ Cosmet Dermatol
January 2025
Cosmetic Research Center, School of Chemical and Material Engineering, Jiangnan University, Wuxi, China.
Background: Excessive lipogenesis of the skin triggers some dermatological concerns, such as enlarged pores, acne, and blackheads. Although topical drug treatments can offer temporary relief, their prolonged usage may lead to side effects of dryness, irritation, or allergic reactions. Consequently, the development of safer and efficacious ingredients in cosmetics for managing sebum overproduction represents a significant yet challenging endeavor.
View Article and Find Full Text PDFNihon Hinyokika Gakkai Zasshi
January 2025
Department of Urology, Osaka Medical and Pharmaceutical University Faculty of Medicine.
A 70-years-old man with metastatic hormone-sensitive prostate cancer received the apalutamide, an oral androgen receptor signaling inhibitor. On day10 after drug initiation, fever and skin rash appeared on his whole-body surface. He stopped taking the drug on day18 and skin symptoms temporarily improved about 7 days after discontinuation.
View Article and Find Full Text PDFAutoimmun Rev
January 2025
Office of Research on Women's Health, Office of the Director, National Institutes of Health, Bethesda, MD, United States of America; Scientific Consulting Group, Gaithersburg, MD, United States of America. Electronic address:
Endometriosis is a female-specific chronic condition that affects 1 in 10 women and other individuals with a uterus worldwide with common symptoms that include pelvic pain and infertility. Reliable and effective non-invasive biomarkers for endometriosis do not exist, and therefore currently a diagnosis of endometriosis requires direct visualization of lesions at surgery. Similarly, few safe and effective management strategies exist for endometriosis, with hormonal interventions and surgery only providing temporary symptom control.
View Article and Find Full Text PDFJ Tissue Viability
January 2025
Department of Pharmaceutics, School of Pharmacy and Technology Management, SVKM'S Narsee Monjee Institute of Management Studies, Shirpur, 425405, Maharashtra, India. Electronic address:
Despite extensive clinical studies and therapeutic interventions, addressing significant skin wounds remains challenging, necessitating novel approaches for effective regeneration therapy. In the current review, we analyzed and evaluated the application, advancements, and future directions of biomaterials-based scaffolds for skin tissue construct. In addition, we investigated the role of other biological substitutes in promoting wound healing and skin tissue regeneration.
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