Therapeutical solutions now can be proposed to some excretory azoospermia, using in vitro-fertilization with epididymal sperm. The encouraging results obtained with this new approach should be analyzed with the genetic risk, sometimes encountered in the specific form of azoospermia due to the congenital absence of the vas deferens. This abnormality is to day supposed to represent a moderate form of cystic fibrosis (CF), corresponding to a genital phenotype of this disease. This suggestion has been firstly induced by similar anatomical findings in the male individuals presenting a classical form of CF. The hypothesis has mainly been confirmed by the real progress in the genetic analysis of this disease. So an abnormally high percentage of known mutations of CF has been demonstrated in the patients with congenital absence of vas deferens. Other arguments such as positive sweat chloride tests, high percentage of sinusitis or presence of anti-pseudomonas antibodies, reinforce this hypothesis. It is the reason why a clinical and biological check-up, prior to any decision of therapy for infertility, in this specific indication should be done in order to propose a genetic counselling to the couple.
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Hormonal, clinical, and genetic profile of infertile patients with azoospermia in Morocco.
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- Azoospermia affects 10-15% of infertile men, with a study in Morocco exploring its clinical, hormonal, and genetic aspects among 80 patients.
- Most participants (96%) experienced primary infertility, with a majority of azoospermia cases being of excretory origin and linked to conditions like hydrocele.
- The study revealed specific hormonal levels, a high prevalence of chromosomal abnormalities (30.7%), and microdeletion rates, highlighting important factors contributing to male infertility in Morocco.
The spectrum of renal involvement in male patients with infertility related to excretory-system abnormalities: phenotypes, genotypes, and genetic counseling.
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Université Paul Sabatier, Toulouse III, Toulouse, France.
Background: While reproductive technologies are increasingly used worldwide, epidemiologic, clinical and genetic data regarding infertile men with combined genital tract and renal abnormalities remain scarce, preventing adequate genetic counseling.
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Department of Morphology, School of Medicine, Autonomous University of Madrid, Madrid, Spain.
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View Article and Find Full Text PDF[Treatment of excretory azoospermia. Biological aspects of surgery].
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Centre Fertily, Clinique de Monplaisir, 10 avenue des Frères Lumière-69008 Lyon.
The therapeutical strategy for excretory azoospermia is very efficient at the present time. It is represented by two complementary methods very different both in their concept and their practical aspects. The surgery for recanalisation of the seminal tract is the old method, associated with reproducible and validated results providing a sophisticated operative methodology which implies microsurgery.
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